A4435G-F11

**Figure 1\. Pedigree diagram for family A4435G\-F11\.**

![](/media/202606/20260622155226686506.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 4435 | m.4435A\>G | A4435G\-F11 | China | Essential hypertension | 7 | 7 | 2018 | [https://kns.cnki.net/kcms2/article/abstract?v\=iB5Z0i9DW\_wNzRd4d\-FKUlEenDGS8kiQLPvClTIgDfMSymkSAwTFzMK2GqvwYyjyQl7sgtyXrv1Cj9N0ko31hP8uoDgXfaD7\-\-gp5pgtsQZGv4seZb0AVZd\_zS50gYm7CYNJAQxvnrp4v0rcVrj1j8O9aVtpU\_zAAQQe\_9Au2MkDTXDt9xPHKA\=\=\&uniplatform\=NZKPT\&language\=CHS](https://kns.cnki.net/kcms2/article/abstract?v=iB5Z0i9DW_wNzRd4d-FKUlEenDGS8kiQLPvClTIgDfMSymkSAwTFzMK2GqvwYyjyQl7sgtyXrv1Cj9N0ko31hP8uoDgXfaD7--gp5pgtsQZGv4seZb0AVZd_zS50gYm7CYNJAQxvnrp4v0rcVrj1j8O9aVtpU_zAAQQe_9Au2MkDTXDt9xPHKA==&uniplatform=NZKPT&language=CHS) |  |

The **m.4435A\>G** variant in MT\-TM was reported in family A4435G\-F11 from China with essential hypertension. The pedigree record reported 7 unaffected and 7 affected maternal relatives, and the carrier table includes 15 listed carriers. Homoplasmy was reported in 0/15 listed carriers; 8/15 carriers were affected, and the main clinical manifestation among affected carriers was high blood presure.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-I2 | Uninf | F | N | Y | D | ND | / | / | / | / | High blood presure |  |
| 2 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-II2 | Fam | F | N | Y | A | ND | / | / | / | / | High blood presure |  |
| 3 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-II4 | Fam | F | N | Y | A | ND | / | / | / | / | High blood presure |  |
| 4 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-II5 | Fam | M | N | Y | A | ND | / | / | / | / | High blood presure |  |
| 5 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-II8 | Fam | F | N | Y | A | ND | / | / | / | / | High blood presure |  |
| 6 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-II10 | Fam | F | N | Y | A | ND | / | / | / | / | High blood presure |  |
| 7 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-II11 | Fam | M | N | Y | A | ND | / | / | / | / | High blood presure |  |
| 8 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-III1 | Fam | M | N | N | A | ND | / | / | / | / | Healthy |  |
| 9 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-III2 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |
| 10 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-III3 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |
| 11 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-III4 | Fam | M | Y | Y | A | ND | / | / | / | / | High blood presure |  |
| 12 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-III5 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |
| 13 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-III8 | Fam | M | N | N | A | ND | / | / | / | / | Healthy |  |
| 14 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-III9 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |
| 15 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-III10 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |

For abbreviations and other usage instructions, please see [Mitofam Info](https://mitofam.com/doc/385/).