A4435G-F4

**Figure 1\. Pedigree diagram for family A4435G\-F4\.**

![](/media/202606/20260622155109746738.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 4435 | m.4435A\>G | A4435G\-F4 | China | Hypertension | 5 | 4 | 2018 | [29211511](https://pubmed.ncbi.nlm.nih.gov/29211511/) | Carrying C5601T |

The **m.4435A\>G** variant in MT\-TM was reported in family A4435G\-F4 from China with hypertension. The pedigree record reported 5 unaffected and 4 affected maternal relatives, and the carrier table includes 10 listed carriers. Homoplasmy was reported in 0/10 listed carriers; 5/10 carriers were affected, and the main clinical manifestation among affected carriers was high blood presure.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-I2 | Uninf | F | N | Y | A | ND | / | / | / | / | High blood presure | Carrying C5601T |
| 2 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-II1 | Fam | M | N | N | A | ND | / | / | / | / | Healthy | Carrying C5601T |
| 3 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-II4 | Fam | F | N | N | A | ND | / | / | / | / | Healthy | Carrying C5601T |
| 4 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-II6 | Fam | F | N | Y | A | ND | / | / | / | / | High blood presure | Carrying C5601T |
| 5 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-II8 | Fam | F | Y | Y | A | ND | / | / | / | / | High blood presure | Carrying C5601T |
| 6 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-III3 | Fam | F | N | Y | A | ND | / | / | / | / | High blood presure | Carrying C5601T |
| 7 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-III4 | Fam | M | N | N | A | ND | / | / | / | / | Healthy | Carrying C5601T |
| 8 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-III6 | Fam | F | N | Y | A | ND | / | / | / | / | High blood presure | Carrying C5601T |
| 9 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-IV1 | Fam | F | N | N | A | ND | / | / | / | / | Healthy | Carrying C5601T |
| 10 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-IV2 | Fam | M | N | N | A | ND | / | / | / | / | Healthy | Carrying C5601T |

For abbreviations and other usage instructions, please see [Mitofam Info](https://mitofam.com/doc/385/).