A4435G

# General Information

| **Position** | **4435** | **Variant** | **m.4435A\>G** | **Locus** | **MT\-TM** | **RNA** | **tRNA Met** |
| --- | --- | --- | --- | --- | --- | --- | --- |
| **Homoplasmy** | \+ | **Heteroplasmy** | \- | **mitoTIP** | 13\.80% | **Pathogenicity** | Reported |

"Pathogenicity" status is derived from published literature or predictions from bioinformatics tools. Researchers and clinicians are cautioned that additional data and/or analysis may still be necessary to confirm the pathological significance of these variants. For more information, please see [Mitofam Info](https://mitofam.com/doc/385/).

# Pedigree Information

The **m.4435A\>G** variant in MT\-TM has been reported in 11 pedigrees. To date, 99 carriers have been reported. Homoplasmy was reported in 35/99 carriers (35\.4%), and 56/99 carriers (56\.6%) were affected. The main clinical manifestations among affected carriers included high blood presure, elevated arterial blood pressure, painless, being the rapid, bilateral loss of central vision, essential hypertension, heart failure, progressive cardiac dysfunction, and other features.

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 4435 | m.4435A\>G | [A4435G\-F1](https://mitofam.com/doc/653/) | China | LHON | 6 | 7 | 2006 | [16431939](https://pubmed.ncbi.nlm.nih.gov/16431939/) | Carrying G11778A |
| 2 | 4435 | m.4435A\>G |[ A4435G\-F2 ](https://mitofam.com/doc/654/)| China | Hypertension | 0 | 2 | 2009 | [19398658](https://pubmed.ncbi.nlm.nih.gov/19398658/) |  |
| 3 | 4435 | m.4435A\>G | [A4435G\-F3](https://mitofam.com/doc/655/) | China | Hypertension | 9 | 8 | 2011 | [21694735](https://pubmed.ncbi.nlm.nih.gov/21694735/) |  |
| 4 | 4435 | m.4435A\>G | [A4435G\-F4 ](https://mitofam.com/doc/656/)| China | Hypertension | 5 | 4 | 2018 | [29211511](https://pubmed.ncbi.nlm.nih.gov/29211511/) | Carrying C5601T |
| 5 | 4435 | m.4435A\>G | A4435G\-F5 | China | Essential hypertension | ND | ND | 2020 | [https://kns.cnki.net/kcms2/article/abstract?v\=9oxawJFDgQVnuL25dAkpk\_kb4LjpzJ5UCbp6P39iuAZQyNddjHbKSO7fxH3exUWNCXETfMi8kFzpX1ZII6rLkT8oDZLgVW9xXuj5\_9B0ni48nBq41N9Od1Ny9l0NL1eaDlSbuaS6B3EQeA6IYA\_e6p6oJzUZqVKeeh\-t9UdseEqoiIKH237gfg\=\=\&uniplatform\=NZKPT\&language\=CHS](https://kns.cnki.net/kcms2/article/abstract?v=9oxawJFDgQVnuL25dAkpk_kb4LjpzJ5UCbp6P39iuAZQyNddjHbKSO7fxH3exUWNCXETfMi8kFzpX1ZII6rLkT8oDZLgVW9xXuj5_9B0ni48nBq41N9Od1Ny9l0NL1eaDlSbuaS6B3EQeA6IYA_e6p6oJzUZqVKeeh-t9UdseEqoiIKH237gfg==&uniplatform=NZKPT&language=CHS) |  |
| 6 | 4435 | m.4435A\>G | [A4435G\-F6](https://mitofam.com/doc/657/) | China | Hypertension | 7 | 7 | 2024 | [38562030](https://pubmed.ncbi.nlm.nih.gov/38562030/) | CarryingYARS2\.G572T |
| 7 | 4435 | m.4435A\>G | A4435G\-F7 | China | DCM | ND | ND | 2022 | [34991096](https://pubmed.ncbi.nlm.nih.gov/34991096/) |  |
| 8 | 4435 | m.4435A\>G | A4435G\-F8 | China | DCM | ND | ND | 2022 | [34991096](https://pubmed.ncbi.nlm.nih.gov/34991096/) |  |
| 9 | 4435 | m.4435A\>G | [A4435G\-F9](https://mitofam.com/doc/658/) | China | Essential hypertension | 1 | 6 | 2020 | [https://kns.cnki.net/kcms2/article/abstract?v\=iB5Z0i9DW\_xy9s76nQVTA0EyBcNc5amhYu8aEvAtP8dK5rbTuY13TtcQ88OmyRr8UFmFMOgtUQ5EQ\_mFME1QWAWw0J69FaBCr1qFOwZ2yFq\-haJTkFfCEjQhoS0KNE\_arM\_vCPDkuGvRslJaBr29kH\-BL2b9HVvp3OLRFYMvzQMhmKc8Wxov5w\=\=\&uniplatform\=NZKPT\&language\=CHS](https://kns.cnki.net/kcms2/article/abstract?v=iB5Z0i9DW_xy9s76nQVTA0EyBcNc5amhYu8aEvAtP8dK5rbTuY13TtcQ88OmyRr8UFmFMOgtUQ5EQ_mFME1QWAWw0J69FaBCr1qFOwZ2yFq-haJTkFfCEjQhoS0KNE_arM_vCPDkuGvRslJaBr29kH-BL2b9HVvp3OLRFYMvzQMhmKc8Wxov5w==&uniplatform=NZKPT&language=CHS) |  |
| 10 | 4435 | m.4435A\>G | [A4435G\-F10](https://mitofam.com/doc/659/) | China | Essential hypertension | 8 | 4 | 2021 | [https://kns.cnki.net/kcms2/article/abstract?v\=iB5Z0i9DW\_xJcPqhhZdQW9R9ARub6UtiRd4PqchH89LdS5UX\-LaKYYpr77Pl2PdNJC2xWI\-g2t0ko36dKhG6a6mtVuXDo7VgYf11tovxrBpF3ToluMliHL5kBdOMD\_HeZJlQosB1qJBtuhCWhPi7boDOgci\-6auwTq2m5WLosvzZ4NKLItyCQQ\=\=\&uniplatform\=NZKPT\&language\=CHS](https://kns.cnki.net/kcms2/article/abstract?v=iB5Z0i9DW_xJcPqhhZdQW9R9ARub6UtiRd4PqchH89LdS5UX-LaKYYpr77Pl2PdNJC2xWI-g2t0ko36dKhG6a6mtVuXDo7VgYf11tovxrBpF3ToluMliHL5kBdOMD_HeZJlQosB1qJBtuhCWhPi7boDOgci-6auwTq2m5WLosvzZ4NKLItyCQQ==&uniplatform=NZKPT&language=CHS) |  |
| 11 | 4435 | m.4435A\>G |[ A4435G\-F11](https://mitofam.com/doc/660/) | China | Essential hypertension | 7 | 7 | 2018 | [https://kns.cnki.net/kcms2/article/abstract?v\=iB5Z0i9DW\_wNzRd4d\-FKUlEenDGS8kiQLPvClTIgDfMSymkSAwTFzMK2GqvwYyjyQl7sgtyXrv1Cj9N0ko31hP8uoDgXfaD7\-\-gp5pgtsQZGv4seZb0AVZd\_zS50gYm7CYNJAQxvnrp4v0rcVrj1j8O9aVtpU\_zAAQQe\_9Au2MkDTXDt9xPHKA\=\=\&uniplatform\=NZKPT\&language\=CHS](https://kns.cnki.net/kcms2/article/abstract?v=iB5Z0i9DW_wNzRd4d-FKUlEenDGS8kiQLPvClTIgDfMSymkSAwTFzMK2GqvwYyjyQl7sgtyXrv1Cj9N0ko31hP8uoDgXfaD7--gp5pgtsQZGv4seZb0AVZd_zS50gYm7CYNJAQxvnrp4v0rcVrj1j8O9aVtpU_zAAQQe_9Au2MkDTXDt9xPHKA==&uniplatform=NZKPT&language=CHS) |  |

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 4435 | m.4435A\>G | A4435G\-F1 | A4435G\-F1\-I2 | Uninf | F | N | N | D | ND | / | / | / | / | Healthy | Carrying G11778A |
| 2 | 4435 | m.4435A\>G | A4435G\-F1 | A4435G\-F1\-II2 | Fam | F | N | N | A | 46 | Homo | / | / | / | Healthy | Carrying G11778A |
| 3 | 4435 | m.4435A\>G | A4435G\-F1 | A4435G\-F1\-II4 | Fam | F | N | Y | A | 51 | Homo | / | / | / | being the rapid, painless,bilateral loss of central vision | Carrying G11778A |
| 4 | 4435 | m.4435A\>G | A4435G\-F1 | A4435G\-F1\-II5 | Fam | M | N | Y | A | 22 | Homo | / | / | / | being the rapid, painless,bilateral loss of central vision | Carrying G11778A |
| 5 | 4435 | m.4435A\>G | A4435G\-F1 | A4435G\-F1\-II6 | Fam | M | N | Y | A | 48 | Homo | / | / | / | being the rapid, painless,bilateral loss of central vision | Carrying G11778A |
| 6 | 4435 | m.4435A\>G | A4435G\-F1 | A4435G\-F1\-II8 | Fam | M | N | Y | A | 41 | Homo | / | / | / | being the rapid, painless,bilateral loss of central vision | Carrying G11778A |
| 7 | 4435 | m.4435A\>G | A4435G\-F1 | A4435G\-F1\-II10 | Fam | M | N | Y | A | 38 | Homo | / | / | / | being the rapid, painless,bilateral loss of central vision | Carrying G11778A |
| 8 | 4435 | m.4435A\>G | A4435G\-F1 | A4435G\-F1\-II13 | Fam | F | N | N | A | 35 | Homo | / | / | / | Healthy | Carrying G11778A |
| 9 | 4435 | m.4435A\>G | A4435G\-F1 | A4435G\-F1\-III1 | Fam | F | N | N | A | 21 | Homo | / | / | / | Healthy | Carrying G11778A |
| 10 | 4435 | m.4435A\>G | A4435G\-F1 | A4435G\-F1\-III2 | Fam | M | Y | Y | A | 18 | Homo | / | / | / | painless, progressive deterioration of bilateral visual impairment | Carrying G11778A |
| 11 | 4435 | m.4435A\>G | A4435G\-F1 | A4435G\-F1\-III3 | Fam | F | N | Y | A | 23 | Homo | / | / | / | being the rapid, painless,bilateral loss of central vision | Carrying G11778A |
| 12 | 4435 | m.4435A\>G | A4435G\-F1 | A4435G\-F1\-III4 | Fam | M | N | Y | A | 19 | Homo | / | / | / | being the rapid, painless,bilateral loss of central vision | Carrying G11778A |
| 13 | 4435 | m.4435A\>G | A4435G\-F1 | A4435G\-F1\-III9 | Fam | F | N | N | A | 11 | Homo | / | / | / | Healthy | Carrying G11778A |
| 14 | 4435 | m.4435A\>G | A4435G\-F1 | A4435G\-F1\-III10 | Fam | M | N | N | A | 7 | Homo | / | / | / | Healthy | Carrying G11778A |
| 15 | 4435 | m.4435A\>G | A4435G\-F2 | A4435G\-F2\-I2 | Uninf | F | N | Y | A | ND | Homo | / | / | / | High blood presure |  |
| 16 | 4435 | m.4435A\>G | A4435G\-F2 | A4435G\-F2\-II1 | Fam | M | Y | Y | A | ND | Homo | / | / | / | High blood presure |  |
| 17 | 4435 | m.4435A\>G | A4435G\-F2 | A4435G\-F2\-II2 | Fam | M | N | Y | A | ND | Homo | / | / | / | High blood presure |  |
| 18 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-I2 | Uninf | F | N | Y | D | 65 | Homo | / | / | / | High blood presure |  |
| 19 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-II2 | Fam | F | N | Y | D | 63 | Homo | / | / | / | High blood presure |  |
| 20 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-II4 | Fam | F | N | Y | A | 64 | Homo | / | / | / | High blood presure |  |
| 21 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-II6 | Fam | F | N | Y | A | 56 | Homo | / | / | / | High blood presure |  |
| 22 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-II8 | Fam | F | N | Y | A | 53 | Homo | / | / | / | High blood presure |  |
| 23 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-II9 | Fam | M | Y | Y | A | 60 | Homo | / | / | / | High blood presure |  |
| 24 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III1 | Fam | M | N | Y | A | 57 | Homo | / | / | / | High blood presure |  |
| 25 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III2 | Fam | M | N | N | A | ND | Homo | / | / | / | Healthy |  |
| 26 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III3 | Fam | M | N | N | A | 48 | Homo | / | / | / | Healthy |  |
| 27 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III4 | Fam | M | N | N | A | 46 | Homo | / | / | / | Healthy |  |
| 28 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III5 | Fam | F | N | Y | A | 51 | Homo | / | / | / | High blood presure |  |
| 29 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III6 | Fam | M | N | N | A | 38 | Homo | / | / | / | Healthy |  |
| 30 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III7 | Fam | M | N | N | A | 38 | Homo | / | / | / | Healthy |  |
| 31 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III8 | Fam | F | N | N | A | 41 | Homo | / | / | / | Healthy |  |
| 32 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III9 | Fam | F | N | N | A | 30 | Homo | / | / | / | Healthy |  |
| 33 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III10 | Fam | F | N | N | A | 33 | Homo | / | / | / | Healthy |  |
| 34 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III11 | Fam | M | N | N | A | 26 | Homo | / | / | / | Healthy |  |
| 35 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-I2 | Uninf | F | N | Y | A | ND | / | / | / | / | High blood presure | Carrying C5601T |
| 36 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-II1 | Fam | M | N | N | A | ND | / | / | / | / | Healthy | Carrying C5601T |
| 37 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-II4 | Fam | F | N | N | A | ND | / | / | / | / | Healthy | Carrying C5601T |
| 38 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-II6 | Fam | F | N | Y | A | ND | / | / | / | / | High blood presure | Carrying C5601T |
| 39 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-II8 | Fam | F | Y | Y | A | ND | / | / | / | / | High blood presure | Carrying C5601T |
| 40 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-III3 | Fam | F | N | Y | A | ND | / | / | / | / | High blood presure | Carrying C5601T |
| 41 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-III4 | Fam | M | N | N | A | ND | / | / | / | / | Healthy | Carrying C5601T |
| 42 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-III6 | Fam | F | N | Y | A | ND | / | / | / | / | High blood presure | Carrying C5601T |
| 43 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-IV1 | Fam | F | N | N | A | ND | / | / | / | / | Healthy | Carrying C5601T |
| 44 | 4435 | m.4435A\>G | A4435G\-F4 | A4435G\-F4\-IV2 | Fam | M | N | N | A | ND | / | / | / | / | Healthy | Carrying C5601T |
| 45 | 4435 | m.4435A\>G | A4435G\-F5 | A4435G\-F5\-P1 | Uninf | F | N | Y | A | ND | / | / | / | / | Essential hypertension |  |
| 46 | 4435 | m.4435A\>G | A4435G\-F5 | A4435G\-F5\-P2 | Uninf | F | N | Y | A | ND | / | / | / | / | Essential hypertension |  |
| 47 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-I2 | Uninf | F | N | Y | D | NA | / | / | / | / | Elevated arterial blood pressure |  |
| 48 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-II1 | Fam | M | N | Y | A | 69 | / | / | / | / | Elevated arterial blood pressure |  |
| 49 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-II3 | Fam | M | N | Y | A | 58 | / | / | / | / | Elevated arterial blood pressure |  |
| 50 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-II6 | Fam | F | N | Y | A | 71 | / | / | / | / | Elevated arterial blood pressure |  |
| 51 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-II8 | Fam | F | N | Y | A | 61 | / | / | / | / | Elevated arterial blood pressure |  |
| 52 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-II10 | Fam | F | N | Y | A | 66 | / | / | / | / | Elevated arterial blood pressure |  |
| 53 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-II12 | Fam | F | N | Y | A | 60 | / | / | / | / | Elevated arterial blood pressure |  |
| 54 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-III5 | Fam | M | N | N | A | 44 | / | / | / | / | Healthy |  |
| 55 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-III6 | Fam | F | N | N | A | 48 | / | / | / | / | Healthy |  |
| 56 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-III7 | Fam | F | N | N | A | 42 | / | / | / | / | Healthy |  |
| 57 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-III8 | Fam | M | Y | Y | A | 37 | / | / | / | / | Elevated arterial blood pressure |  |
| 58 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-III9 | Fam | F | N | N | A | 33 | / | / | / | / | Healthy |  |
| 59 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-III10 | Fam | M | N | N | A | 45 | / | / | / | / | Healthy |  |
| 60 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-III11 | Fam | F | N | N | A | 34 | / | / | / | / | Healthy |  |
| 61 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-III12 | Fam | F | N | N | A | 28 | / | / | / | / | Healthy |  |
| 62 | 4435 | m.4435A\>G | A4435G\-F7 | A4435G\-F7\-P1 | Fam | M | Y | Y | A | 72 | Homo | / | / | / | Heart failure |  |
| 63 | 4435 | m.4435A\>G | A4435G\-F8 | A4435G\-F8\-P1 | De novo | F | Y | Y | A | 51 | Homo | / | / | / | Progressive cardiac dysfunction |  |
| 64 | 4435 | m.4435A\>G | A4435G\-F9 | A4435G\-F9\-I2 | Uninf | F | N | Y | D | ND | / | / | / | / | Essential hypertension |  |
| 65 | 4435 | m.4435A\>G | A4435G\-F9 | A4435G\-F9\-II1 | Fam | M | N | Y | A | ND | / | / | / | / | Essential hypertension |  |
| 66 | 4435 | m.4435A\>G | A4435G\-F9 | A4435G\-F9\-II3 | Fam | M | Y | Y | A | 60 | / | / | / | / | Essential hypertension |  |
| 67 | 4435 | m.4435A\>G | A4435G\-F9 | A4435G\-F9\-II6 | Fam | F | N | Y | A | 56 | / | / | / | / | Essential hypertension |  |
| 68 | 4435 | m.4435A\>G | A4435G\-F9 | A4435G\-F9\-II8 | Fam | F | N | Y | A | 53 | / | / | / | / | Essential hypertension |  |
| 69 | 4435 | m.4435A\>G | A4435G\-F9 | A4435G\-F9\-III6 | Fam | M | N | Y | A | ND | / | / | / | / | Essential hypertension |  |
| 70 | 4435 | m.4435A\>G | A4435G\-F9 | A4435G\-F9\-III7 | Uninf | M | N | N | A | NA | / | / | / | / | Healthy |  |
| 71 | 4435 | m.4435A\>G | A4435G\-F9 | A4435G\-F9\-III8 | Fam | M | N | Y | A | 36 | / | / | / | / | Essential hypertension |  |
| 72 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-I2 | Uninf | F | N | Y | D | ND | / | / | / | / | Healthy |  |
| 73 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-II2 | Fam | F | N | Y | A | 66 | / | / | / | / | High blood presure |  |
| 74 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-II4 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |
| 75 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-II6 | Fam | F | N | Y | A | 63 | / | / | / | / | High blood presure |  |
| 76 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-III1 | Fam | M | N | Y | A | 42 | / | / | / | / | High blood presure |  |
| 77 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-III2 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |
| 78 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-III3 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |
| 79 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-III4 | Fam | M | N | N | A | ND | / | / | / | / | Healthy |  |
| 80 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-III5 | Fam | M | N | N | A | ND | / | / | / | / | Healthy |  |
| 81 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-III6 | Fam | F | Y | Y | A | 37 | / | / | / | / | High blood presure |  |
| 82 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-III7 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |
| 83 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-III8 | Fam | F | N | N | A | 29 | / | / | / | / | Healthy |  |
| 84 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-III9 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |
| 85 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-I2 | Uninf | F | N | Y | D | ND | / | / | / | / | High blood presure |  |
| 86 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-II2 | Fam | F | N | Y | A | ND | / | / | / | / | High blood presure |  |
| 87 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-II4 | Fam | F | N | Y | A | ND | / | / | / | / | High blood presure |  |
| 88 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-II5 | Fam | M | N | Y | A | ND | / | / | / | / | High blood presure |  |
| 89 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-II8 | Fam | F | N | Y | A | ND | / | / | / | / | High blood presure |  |
| 90 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-II10 | Fam | F | N | Y | A | ND | / | / | / | / | High blood presure |  |
| 91 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-II11 | Fam | M | N | Y | A | ND | / | / | / | / | High blood presure |  |
| 92 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-III1 | Fam | M | N | N | A | ND | / | / | / | / | Healthy |  |
| 93 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-III2 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |
| 94 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-III3 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |
| 95 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-III4 | Fam | M | Y | Y | A | ND | / | / | / | / | High blood presure |  |
| 96 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-III5 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |
| 97 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-III8 | Fam | M | N | N | A | ND | / | / | / | / | Healthy |  |
| 98 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-III9 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |
| 99 | 4435 | m.4435A\>G | A4435G\-F11 | A4435G\-F11\-III10 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |

For abbreviations and other usage instructions, please see [Mitofam Info](https://mitofam.com/doc/385/).