A4435G-F9

**Figure 1\. Pedigree diagram for family A4435G\-F9\.**

![](/media/202606/20260622155153911587.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 4435 | m.4435A\>G | A4435G\-F9 | China | Essential hypertension | 1 | 6 | 2020 | [https://kns.cnki.net/kcms2/article/abstract?v\=iB5Z0i9DW\_xy9s76nQVTA0EyBcNc5amhYu8aEvAtP8dK5rbTuY13TtcQ88OmyRr8UFmFMOgtUQ5EQ\_mFME1QWAWw0J69FaBCr1qFOwZ2yFq\-haJTkFfCEjQhoS0KNE\_arM\_vCPDkuGvRslJaBr29kH\-BL2b9HVvp3OLRFYMvzQMhmKc8Wxov5w\=\=\&uniplatform\=NZKPT\&language\=CHS](https://kns.cnki.net/kcms2/article/abstract?v=iB5Z0i9DW_xy9s76nQVTA0EyBcNc5amhYu8aEvAtP8dK5rbTuY13TtcQ88OmyRr8UFmFMOgtUQ5EQ_mFME1QWAWw0J69FaBCr1qFOwZ2yFq-haJTkFfCEjQhoS0KNE_arM_vCPDkuGvRslJaBr29kH-BL2b9HVvp3OLRFYMvzQMhmKc8Wxov5w==&uniplatform=NZKPT&language=CHS) |  |

The **m.4435A\>G** variant in MT\-TM was reported in family A4435G\-F9 from China with essential hypertension. The pedigree record reported 1 unaffected and 6 affected maternal relatives, and the carrier table includes 8 listed carriers. Homoplasmy was reported in 0/8 listed carriers; 7/8 carriers were affected, and the main clinical manifestation among affected carriers was not available.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 4435 | m.4435A\>G | A4435G\-F9 | A4435G\-F9\-I2 | Uninf | F | N | Y | D | ND | / | / | / | / | Essential hypertension |  |
| 2 | 4435 | m.4435A\>G | A4435G\-F9 | A4435G\-F9\-II1 | Fam | M | N | Y | A | ND | / | / | / | / | Essential hypertension |  |
| 3 | 4435 | m.4435A\>G | A4435G\-F9 | A4435G\-F9\-II3 | Fam | M | Y | Y | A | 60 | / | / | / | / | Essential hypertension |  |
| 4 | 4435 | m.4435A\>G | A4435G\-F9 | A4435G\-F9\-II6 | Fam | F | N | Y | A | 56 | / | / | / | / | Essential hypertension |  |
| 5 | 4435 | m.4435A\>G | A4435G\-F9 | A4435G\-F9\-II8 | Fam | F | N | Y | A | 53 | / | / | / | / | Essential hypertension |  |
| 6 | 4435 | m.4435A\>G | A4435G\-F9 | A4435G\-F9\-III6 | Fam | M | N | Y | A | ND | / | / | / | / | Essential hypertension |  |
| 7 | 4435 | m.4435A\>G | A4435G\-F9 | A4435G\-F9\-III7 | Uninf | M | N | N | A | NA | / | / | / | / | Healthy |  |
| 8 | 4435 | m.4435A\>G | A4435G\-F9 | A4435G\-F9\-III8 | Fam | M | N | Y | A | 36 | / | / | / | / | Essential hypertension |  |

For abbreviations and other usage instructions, please see [Mitofam Info](https://mitofam.com/doc/385/).