A4435G-F6

**Figure 1\. Pedigree diagram for family A4435G\-F6\.**

![](/media/202606/20260622155130735692.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 4435 | m.4435A\>G | A4435G\-F6 | China | Hypertension | 7 | 7 | 2024 | [38562030](https://pubmed.ncbi.nlm.nih.gov/38562030/) | CarryingYARS2\.G572T |

The **m.4435A\>G** variant in MT\-TM was reported in family A4435G\-F6 from China with hypertension. The pedigree record reported 7 unaffected and 7 affected maternal relatives, and the carrier table includes 15 listed carriers. Homoplasmy was reported in 0/15 listed carriers; 8/15 carriers were affected, and the main clinical manifestation among affected carriers was elevated arterial blood pressure.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-I2 | Uninf | F | N | Y | D | NA | / | / | / | / | Elevated arterial blood pressure |  |
| 2 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-II1 | Fam | M | N | Y | A | 69 | / | / | / | / | Elevated arterial blood pressure |  |
| 3 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-II3 | Fam | M | N | Y | A | 58 | / | / | / | / | Elevated arterial blood pressure |  |
| 4 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-II6 | Fam | F | N | Y | A | 71 | / | / | / | / | Elevated arterial blood pressure |  |
| 5 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-II8 | Fam | F | N | Y | A | 61 | / | / | / | / | Elevated arterial blood pressure |  |
| 6 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-II10 | Fam | F | N | Y | A | 66 | / | / | / | / | Elevated arterial blood pressure |  |
| 7 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-II12 | Fam | F | N | Y | A | 60 | / | / | / | / | Elevated arterial blood pressure |  |
| 8 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-III5 | Fam | M | N | N | A | 44 | / | / | / | / | Healthy |  |
| 9 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-III6 | Fam | F | N | N | A | 48 | / | / | / | / | Healthy |  |
| 10 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-III7 | Fam | F | N | N | A | 42 | / | / | / | / | Healthy |  |
| 11 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-III8 | Fam | M | Y | Y | A | 37 | / | / | / | / | Elevated arterial blood pressure |  |
| 12 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-III9 | Fam | F | N | N | A | 33 | / | / | / | / | Healthy |  |
| 13 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-III10 | Fam | M | N | N | A | 45 | / | / | / | / | Healthy |  |
| 14 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-III11 | Fam | F | N | N | A | 34 | / | / | / | / | Healthy |  |
| 15 | 4435 | m.4435A\>G | A4435G\-F6 | A4435G\-F6\-III12 | Fam | F | N | N | A | 28 | / | / | / | / | Healthy |  |

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