A4435G-F10

**Figure 1\. Pedigree diagram for family A4435G\-F10\.**

![](/media/202606/20260622155211301589.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 4435 | m.4435A\>G | A4435G\-F10 | China | Essential hypertension | 8 | 4 | 2021 | [https://kns.cnki.net/kcms2/article/abstract?v\=iB5Z0i9DW\_xJcPqhhZdQW9R9ARub6UtiRd4PqchH89LdS5UX\-LaKYYpr77Pl2PdNJC2xWI\-g2t0ko36dKhG6a6mtVuXDo7VgYf11tovxrBpF3ToluMliHL5kBdOMD\_HeZJlQosB1qJBtuhCWhPi7boDOgci\-6auwTq2m5WLosvzZ4NKLItyCQQ\=\=\&uniplatform\=NZKPT\&language\=CHS](https://kns.cnki.net/kcms2/article/abstract?v=iB5Z0i9DW_xJcPqhhZdQW9R9ARub6UtiRd4PqchH89LdS5UX-LaKYYpr77Pl2PdNJC2xWI-g2t0ko36dKhG6a6mtVuXDo7VgYf11tovxrBpF3ToluMliHL5kBdOMD_HeZJlQosB1qJBtuhCWhPi7boDOgci-6auwTq2m5WLosvzZ4NKLItyCQQ==&uniplatform=NZKPT&language=CHS) |  |

The **m.4435A\>G** variant in MT\-TM was reported in family A4435G\-F10 from China with essential hypertension. The pedigree record reported 8 unaffected and 4 affected maternal relatives, and the carrier table includes 13 listed carriers. Homoplasmy was reported in 0/13 listed carriers; 5/13 carriers were affected, and the main clinical manifestation among affected carriers was high blood presure.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-I2 | Uninf | F | N | Y | D | ND | / | / | / | / | Healthy |  |
| 2 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-II2 | Fam | F | N | Y | A | 66 | / | / | / | / | High blood presure |  |
| 3 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-II4 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |
| 4 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-II6 | Fam | F | N | Y | A | 63 | / | / | / | / | High blood presure |  |
| 5 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-III1 | Fam | M | N | Y | A | 42 | / | / | / | / | High blood presure |  |
| 6 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-III2 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |
| 7 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-III3 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |
| 8 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-III4 | Fam | M | N | N | A | ND | / | / | / | / | Healthy |  |
| 9 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-III5 | Fam | M | N | N | A | ND | / | / | / | / | Healthy |  |
| 10 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-III6 | Fam | F | Y | Y | A | 37 | / | / | / | / | High blood presure |  |
| 11 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-III7 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |
| 12 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-III8 | Fam | F | N | N | A | 29 | / | / | / | / | Healthy |  |
| 13 | 4435 | m.4435A\>G | A4435G\-F10 | A4435G\-F10\-III9 | Fam | F | N | N | A | ND | / | / | / | / | Healthy |  |

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