A4435G-F3

**Figure 1\. Pedigree diagram for family A4435G\-F3\.**

![](/media/202606/20260622155051391971.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 4435 | m.4435A\>G | A4435G\-F3 | China | Hypertension | 9 | 8 | 2011 | [21694735](https://pubmed.ncbi.nlm.nih.gov/21694735/) |  |

The **m.4435A\>G** variant in MT\-TM was reported in family A4435G\-F3 from China with hypertension. The pedigree record reported 9 unaffected and 8 affected maternal relatives, and the carrier table includes 17 listed carriers. Homoplasmy was reported in all listed carriers; 8/17 carriers were affected, and the main clinical manifestation among affected carriers was high blood presure.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-I2 | Uninf | F | N | Y | D | 65 | Homo | / | / | / | High blood presure |  |
| 2 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-II2 | Fam | F | N | Y | D | 63 | Homo | / | / | / | High blood presure |  |
| 3 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-II4 | Fam | F | N | Y | A | 64 | Homo | / | / | / | High blood presure |  |
| 4 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-II6 | Fam | F | N | Y | A | 56 | Homo | / | / | / | High blood presure |  |
| 5 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-II8 | Fam | F | N | Y | A | 53 | Homo | / | / | / | High blood presure |  |
| 6 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-II9 | Fam | M | Y | Y | A | 60 | Homo | / | / | / | High blood presure |  |
| 7 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III1 | Fam | M | N | Y | A | 57 | Homo | / | / | / | High blood presure |  |
| 8 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III2 | Fam | M | N | N | A | ND | Homo | / | / | / | Healthy |  |
| 9 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III3 | Fam | M | N | N | A | 48 | Homo | / | / | / | Healthy |  |
| 10 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III4 | Fam | M | N | N | A | 46 | Homo | / | / | / | Healthy |  |
| 11 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III5 | Fam | F | N | Y | A | 51 | Homo | / | / | / | High blood presure |  |
| 12 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III6 | Fam | M | N | N | A | 38 | Homo | / | / | / | Healthy |  |
| 13 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III7 | Fam | M | N | N | A | 38 | Homo | / | / | / | Healthy |  |
| 14 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III8 | Fam | F | N | N | A | 41 | Homo | / | / | / | Healthy |  |
| 15 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III9 | Fam | F | N | N | A | 30 | Homo | / | / | / | Healthy |  |
| 16 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III10 | Fam | F | N | N | A | 33 | Homo | / | / | / | Healthy |  |
| 17 | 4435 | m.4435A\>G | A4435G\-F3 | A4435G\-F3\-III11 | Fam | M | N | N | A | 26 | Homo | / | / | / | Healthy |  |

For abbreviations and other usage instructions, please see [Mitofam Info](https://mitofam.com/doc/385/).