G11778A-F341

**Figure 1\. Pedigree diagram for family G11778A\-F341\.**

![](/media/202606/20260630170029421582.png)

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# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 11778 | m.11778G\>A | G11778A\-F341 | Thailand | LHON | ND | ND | 2006 | [17072496](https://pubmed.ncbi.nlm.nih.gov/17072496/) |  |

The **m.11778G\>A** variant in MT\-ND4 was reported in family G11778A\-F341 from Thailand with lhon. The pedigree record reported ND unaffected and ND affected maternal relatives, and the carrier table includes 15 listed carriers. Homoplasmy was reported in all listed carriers; 7/15 carriers were affected, and the main clinical manifestation among affected carriers was lhon.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 11778 | m.11778G\>A | G11778A\-F341 | G11778A\-F341\-II1 | Fam | ND | N | N | ND | ND | Homo | / | / | / | Healthy |  |
| 2 | 11778 | m.11778G\>A | G11778A\-F341 | G11778A\-F341\-II2 | Fam | ND | N | N | ND | ND | Homo | / | / | / | Healthy |  |
| 3 | 11778 | m.11778G\>A | G11778A\-F341 | G11778A\-F341\-II3 | Fam | ND | N | Y | ND | ND | Homo | / | / | / | LHON |  |
| 4 | 11778 | m.11778G\>A | G11778A\-F341 | G11778A\-F341\-II4 | Fam | ND | N | Y | ND | ND | Homo | / | / | / | LHON |  |
| 5 | 11778 | m.11778G\>A | G11778A\-F341 | G11778A\-F341\-II5 | Fam | ND | N | Y | ND | ND | Homo | / | / | / | LHON |  |
| 6 | 11778 | m.11778G\>A | G11778A\-F341 | G11778A\-F341\-II6 | Fam | ND | N | N | ND | ND | Homo | / | / | / | Healthy |  |
| 7 | 11778 | m.11778G\>A | G11778A\-F341 | G11778A\-F341\-II7 | Fam | ND | N | Y | ND | ND | Homo | / | / | / | LHON |  |
| 8 | 11778 | m.11778G\>A | G11778A\-F341 | G11778A\-F341\-II8 | Fam | ND | N | ND | ND | ND | Homo | / | / | / | Possible fundus abnormality/no vision loss |  |
| 9 | 11778 | m.11778G\>A | G11778A\-F341 | G11778A\-F341\-II9 | Fam | ND | N | Y | ND | ND | Homo | / | / | / | LHON |  |
| 10 | 11778 | m.11778G\>A | G11778A\-F341 | G11778A\-F341\-II10 | Fam | ND | N | Y | ND | ND | Homo | / | / | / | LHON |  |
| 11 | 11778 | m.11778G\>A | G11778A\-F341 | G11778A\-F341\-II11 | Fam | ND | N | N | ND | ND | Homo | / | / | / | Healthy |  |
| 12 | 11778 | m.11778G\>A | G11778A\-F341 | G11778A\-F341\-II12 | Fam | ND | N | N | ND | ND | Homo | / | / | / | Healthy |  |
| 13 | 11778 | m.11778G\>A | G11778A\-F341 | G11778A\-F341\-II13 | Fam | ND | N | N | ND | ND | Homo | / | / | / | Healthy |  |
| 14 | 11778 | m.11778G\>A | G11778A\-F341 | G11778A\-F341\-II14 | Fam | ND | N | ND | ND | ND | Homo | / | / | / | Possible fundus abnormality/no vision loss |  |
| 15 | 11778 | m.11778G\>A | G11778A\-F341 | G11778A\-F341\-II15 | Fam | ND | Y | Y | ND | ND | Homo | / | / | / | LHON |  |

For abbreviations and other usage instructions, please see [Mitofam Info](https://mitofam.com/doc/385/).