G11778A-F339

**Figure 1\. Pedigree diagram for family G11778A\-F339\.**

![](/media/202606/20260630165908803639.png)

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# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 11778 | m.11778G\>A | G11778A\-F339 | Thailand | LHON | ND | ND | 2006 | [17072496](https://pubmed.ncbi.nlm.nih.gov/17072496/) |  |

The **m.11778G\>A** variant in MT\-ND4 was reported in family G11778A\-F339 from Thailand with lhon. The pedigree record reported ND unaffected and ND affected maternal relatives, and the carrier table includes 12 listed carriers. Homoplasmy was reported in 4/12 listed carriers; 1/12 carriers were affected, and the main clinical manifestation among affected carriers was lhon.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 11778 | m.11778G\>A | G11778A\-F339 | G11778A\-F339\-II1 | Fam | ND | N | N | ND | ND | 4% | / | / | / | Healthy |  |
| 2 | 11778 | m.11778G\>A | G11778A\-F339 | G11778A\-F339\-II2 | Fam | ND | N | N | ND | ND | 37% | / | / | / | Healthy |  |
| 3 | 11778 | m.11778G\>A | G11778A\-F339 | G11778A\-F339\-II3 | Fam | ND | N | N | ND | ND | 3% | / | / | / | Healthy |  |
| 4 | 11778 | m.11778G\>A | G11778A\-F339 | G11778A\-F339\-II4 | Fam | ND | N | N | ND | ND | 59% | / | / | / | Healthy |  |
| 5 | 11778 | m.11778G\>A | G11778A\-F339 | G11778A\-F339\-II5 | Fam | ND | N | N | ND | ND | 44% | / | / | / | Healthy |  |
| 6 | 11778 | m.11778G\>A | G11778A\-F339 | G11778A\-F339\-II6 | Fam | ND | N | N | ND | ND | Homo | / | / | / | Healthy |  |
| 7 | 11778 | m.11778G\>A | G11778A\-F339 | G11778A\-F339\-II7 | Fam | ND | N | N | ND | ND | Homo | / | / | / | Healthy |  |
| 8 | 11778 | m.11778G\>A | G11778A\-F339 | G11778A\-F339\-II8 | Fam | ND | N | N | ND | ND | 94% | / | / | / | Healthy |  |
| 9 | 11778 | m.11778G\>A | G11778A\-F339 | G11778A\-F339\-II9 | Fam | ND | Y | Y | ND | ND | Homo | / | / | / | LHON |  |
| 10 | 11778 | m.11778G\>A | G11778A\-F339 | G11778A\-F339\-II10 | Fam | ND | N | N | ND | ND | 1% | / | / | / | Healthy |  |
| 11 | 11778 | m.11778G\>A | G11778A\-F339 | G11778A\-F339\-II11 | Fam | ND | N | N | ND | ND | 76% | / | / | / | Healthy |  |
| 12 | 11778 | m.11778G\>A | G11778A\-F339 | G11778A\-F339\-II12 | Fam | ND | N | N | ND | ND | Homo | / | / | / | Healthy |  |

For abbreviations and other usage instructions, please see [Mitofam Info](https://mitofam.com/doc/385/).