G11778A-F5

**Figure 1\. Pedigree diagram for family G11778A\-F5\.**

![](/media/202606/20260630155211739189.png)

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# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 11778 | m.11778G\>A | G11778A\-F5 | Canada | LHON | 8 | 0 | 1992 | [1346348](https://pubmed.ncbi.nlm.nih.gov/1346348/) | Paper pedigree D |

The **m.11778G\>A** variant in MT\-ND4 was reported in family G11778A\-F5 from Canada with lhon. The pedigree record reported 8 unaffected and 0 affected maternal relatives, and the carrier table includes 9 listed carriers. Homoplasmy was reported in 0/9 listed carriers; 1/9 carriers were affected, and the main clinical manifestation among affected carriers was lhon, visual loss onset age 24\.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 11778 | m.11778G\>A | G11778A\-F5 | G11778A\-F5\-II1 | Fam | F | N | N | D | 89 | 32% | / | / | / | Healthy | Original carrier identifier: D\-II\-2 |
| 2 | 11778 | m.11778G\>A | G11778A\-F5 | G11778A\-F5\-III1 | Fam | F | N | N | A | 66 | 80% | / | / | / | Healthy | Original carrier identifier: D\-III\-1 |
| 3 | 11778 | m.11778G\>A | G11778A\-F5 | G11778A\-F5\-IV1 | Fam | F | N | N | A | 36 | 90% | / | / | / | Healthy | Original carrier identifier: D\-IV\-1 |
| 4 | 11778 | m.11778G\>A | G11778A\-F5 | G11778A\-F5\-IV2 | Fam | M | N | N | A | 34 | 37% | / | / | / | Healthy | Original carrier identifier: D\-IV\-2 |
| 5 | 11778 | m.11778G\>A | G11778A\-F5 | G11778A\-F5\-IV3 | Fam | F | N | N | A | 33 | 80% | / | / | / | Healthy | Original carrier identifier: D\-IV\-3 |
| 6 | 11778 | m.11778G\>A | G11778A\-F5 | G11778A\-F5\-IV4 | Fam | F | Y | Y | A | 30 | 62% | / | / | / | LHON; visual loss onset age 24 | Original carrier identifier: D\-IV\-4 |
| 7 | 11778 | m.11778G\>A | G11778A\-F5 | G11778A\-F5\-IV5 | Fam | M | N | N | A | 29 | 55% | / | / | / | Healthy | Original carrier identifier: D\-IV\-5 |
| 8 | 11778 | m.11778G\>A | G11778A\-F5 | G11778A\-F5\-IV6 | Fam | F | N | N | A | 27 | 89% | / | / | / | Healthy | Original carrier identifier: D\-IV\-6 |
| 9 | 11778 | m.11778G\>A | G11778A\-F5 | G11778A\-F5\-IV7 | Fam | F | N | N | A | 25 | 91% | / | / | / | Healthy | Original carrier identifier: D\-IV\-7 |

For abbreviations and other usage instructions, please see [Mitofam Info](https://mitofam.com/doc/385/).