C11777A-F7

**Figure 1\. Pedigree diagram for family C11777A\-F7\.**

![](/media/202606/20260630154634513872.png)

|  |
| --- |

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 11777 | m.11777C\>A | C11777A\-F7 | United Kingdom | Prenatal mitochondrial disease testing | 1 | 0 | 2014 | [24642831](https://pubmed.ncbi.nlm.nih.gov/24642831/) |  |

The **m.11777C\>A** variant in MT\-ND4 was reported in family C11777A\-F7 from United Kingdom with prenatal mitochondrial disease testing. The pedigree record reported 1 unaffected and 0 affected maternal relatives, and the carrier table includes 2 listed carriers. Homoplasmy was reported in 0/2 listed carriers; 0/2 carriers were affected, and the main clinical manifestation among affected carriers was not available.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 11777 | m.11777C\>A | C11777A\-F7 | C11777A\-F7\-II1 | Fam | ND | N | N | A | 5 years | / | / | / | 54%(CVB) | Healthy |  |
| 2 | 11777 | m.11777C\>A | C11777A\-F7 | C11777A\-F7\-I1 | Uninf | F | Y | ND | A | ND | 18% | / | 32% | 20%(BM) | ND |  |

For abbreviations and other usage instructions, please see [Mitofam Info](https://mitofam.com/doc/385/).