G11696A-F7

**Figure 1\. Pedigree diagram for family G11696A\-F7\.**

![](/media/202606/20260630154920164558.png)

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# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 11696 | m.11696G\>A | G11696A\-F7 | China | Aminoglycoside\-induced and nonsyndromic hearing loss | 9 | 9 | 2007 | [17723226](https://pubmed.ncbi.nlm.nih.gov/17723226/) | Coexisting variant: coexisting A1555G |

The **m.11696G\>A** variant in MT\-ND4 was reported in family G11696A\-F7 from China with aminoglycoside\-induced and nonsyndromic hearing loss. The pedigree record reported 9 unaffected and 9 affected maternal relatives, and the carrier table includes 11 listed carriers. Homoplasmy was reported in all listed carriers; 10/11 carriers were affected, and the main clinical manifestation among affected carriers was sensorineural hearing loss, severe, moderate, mild, aminoglycoside\-induced sensorineural hearing loss.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 11696 | m.11696G\>A | G11696A\-F7 | G11696A\-F7\-II1 | Fam | F | N | Y | ND | ND | Homo | / | / | / | Sensorineural hearing loss; severe | Coexisting variant: A1555G |
| 2 | 11696 | m.11696G\>A | G11696A\-F7 | G11696A\-F7\-II2 | Fam | M | N | Y | ND | ND | Homo | / | / | / | Sensorineural hearing loss; severe | Coexisting variant: A1555G |
| 3 | 11696 | m.11696G\>A | G11696A\-F7 | G11696A\-F7\-III1 | Fam | F | N | Y | ND | ND | Homo | / | / | / | Sensorineural hearing loss; moderate | Coexisting variant: A1555G |
| 4 | 11696 | m.11696G\>A | G11696A\-F7 | G11696A\-F7\-III2 | Fam | F | N | Y | ND | ND | Homo | / | / | / | Sensorineural hearing loss; moderate | Coexisting variant: A1555G |
| 5 | 11696 | m.11696G\>A | G11696A\-F7 | G11696A\-F7\-III3 | Fam | M | N | Y | ND | ND | Homo | / | / | / | Sensorineural hearing loss; mild | Coexisting variant: A1555G |
| 6 | 11696 | m.11696G\>A | G11696A\-F7 | G11696A\-F7\-III4 | Fam | F | N | Y | ND | ND | Homo | / | / | / | Sensorineural hearing loss; severe | Coexisting variant: A1555G |
| 7 | 11696 | m.11696G\>A | G11696A\-F7 | G11696A\-F7\-III5 | Fam | M | N | Y | ND | ND | Homo | / | / | / | Sensorineural hearing loss; severe | Coexisting variant: A1555G |
| 8 | 11696 | m.11696G\>A | G11696A\-F7 | G11696A\-F7\-III6 | Fam | F | N | Y | ND | ND | Homo | / | / | / | Sensorineural hearing loss; moderate | Coexisting variant: A1555G |
| 9 | 11696 | m.11696G\>A | G11696A\-F7 | G11696A\-F7\-IV1 | Fam | F | Y | Y | ND | 17 | Homo | / | / | / | Aminoglycoside\-induced sensorineural hearing loss; moderate | Coexisting variant: A1555G |
| 10 | 11696 | m.11696G\>A | G11696A\-F7 | G11696A\-F7\-IV2 | Fam | F | N | Y | ND | ND | Homo | / | / | / | Aminoglycoside\-induced sensorineural hearing loss; severe | Coexisting variant: A1555G |
| 11 | 11696 | m.11696G\>A | G11696A\-F7 | G11696A\-F7\-III7 | Fam | M | N | N | ND | ND | Homo | / | / | / | Healthy | Coexisting variant: A1555G |

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