T14709C-F4

**Figure 1\. Pedigree diagram for family T14709C\-F4\.**

![](/media/202606/20260626171615706484.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 14709 | m.14709T\>C | T14709C\-F4 | USA | Myopathy, diabetes mellitus | 1 | 1 | 1999 | [10392369](https://pubmed.ncbi.nlm.nih.gov/10392369/) |  |

The **m.14709T\>C** variant in MT\-TE was reported in family T14709C\-F4 from USA with myopathy, diabetes mellitus. The pedigree record reported 1 unaffected and 1 affected maternal relatives, and the carrier table includes 3 listed carriers. Homoplasmy was reported in 0/3 listed carriers; 2/3 carriers were affected, and the main clinical manifestation among affected carriers was mitochondrial myopathy, diabetes mellitus, peripheral neuropathy, ataxia, learning problems.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 14709 | m.14709T\>C | T14709C\-F4 | T14709C\-F4\-I2 | Uninf | F | N | Y | A | 25 | \>95% | / | / | / | Mitochondrial myopathy, diabetes mellitus, peripheral neuropathy |  |
| 2 | 14709 | m.14709T\>C | T14709C\-F4 | T14709C\-F4\-II2 | Fam | M | N | N | A | ND | / | / | / | / | Healthy |  |
| 3 | 14709 | m.14709T\>C | T14709C\-F4 | T14709C\-F4\-II1 | Fam | M | Y | Y | A | 20 | \>95% | / | / | / | Mitochondrial myopathy, diabetes mellitus, ataxia, learning problems |  |

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