T14674C-F11

**Figure 1\. Pedigree diagram for family T14674C\-F11\.**

![](/media/202606/20260626171132991684.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 14674 | m.14674T\>C | T14674C\-F11 | Italy | Feeding and respiratory difficulties | ND | ND | 2011 | [21931168](https://pubmed.ncbi.nlm.nih.gov/21931168/) |  |

The **m.14674T\>C** variant in MT\-TE was reported in family T14674C\-F11 from Italy with feeding and respiratory difficulties. The pedigree record reported ND unaffected and ND affected maternal relatives, and the carrier table includes 2 listed carriers. Homoplasmy was reported in 1/2 listed carriers; 2/2 carriers were affected, and the main clinical manifestation among affected carriers was feeding and respiratory difficulties, mild facial weakness.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 14674 | m.14674T\>C | T14674C\-F11 | T14674C\-F11\-II1 | Fam | F | Y | Y | A | 15 | Homo | / | / | Homo (saliva) | Feeding and respiratory difficulties |  |
| 2 | 14674 | m.14674T\>C | T14674C\-F11 | T14674C\-F11\-I2 | Uninf | F | N | Y | A | ND | / | / | / | Homo (tissue not specified) | Mild facial weakness |  |

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