A14693G-F4

**Figure 1\. Pedigree diagram for family A14693G\-F4\.**

![](/media/202606/20260626170404457588.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 14693 | m.14693A\>G | A14693G\-F4 | China | Hypertension | 6 | 4 | 2024 | [38222291](https://pubmed.ncbi.nlm.nih.gov/38222291/) |  |

The **m.14693A\>G** variant in MT\-TE was reported in family A14693G\-F4 from China with hypertension. The pedigree record reported 6 unaffected and 4 affected maternal relatives, and the carrier table includes 4 listed carriers. Homoplasmy was reported in all listed carriers; 4/4 carriers were affected, and the main clinical manifestation among affected carriers was hypertension.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 14693 | m.14693A\>G | A14693G\-F4 | A14693G\-F4\-II6 | Fam | F | Y | Y | A | 75 | Homo | / | / | / | Hypertension |  |
| 2 | 14693 | m.14693A\>G | A14693G\-F4 | A14693G\-F4\-II8 | Fam | F | N | Y | A | 72 | Homo | / | / | / | Hypertension |  |
| 3 | 14693 | m.14693A\>G | A14693G\-F4 | A14693G\-F4\-III3 | Fam | F | N | Y | A | 50 | Homo | / | / | / | Hypertension |  |
| 4 | 14693 | m.14693A\>G | A14693G\-F4 | A14693G\-F4\-III10 | Fam | F | N | Y | A | 45 | Homo | / | / | / | Hypertension |  |

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