A7445G-F6

**Figure 1\. Pedigree diagram for family A7445G\-F6\.**

![](/media/202606/20260626162433683624.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 7445 | m.7445A\>G | A7445G\-F6 | Hungary | Nonsyndromic sensorineural hearing loss | 3 | 2 | 2008 | [18537605](https://pubmed.ncbi.nlm.nih.gov/18537605/) |  |

The **m.7445A\>G** variant in MT\-CO1 was reported in family A7445G\-F6 from Hungary with nonsyndromic sensorineural hearing loss. The pedigree record reported 3 unaffected and 2 affected maternal relatives, and the carrier table includes 3 listed carriers. Homoplasmy was reported in 2/3 listed carriers; 1/3 carriers were affected, and the main clinical manifestation among affected carriers was sensorineural hearing loss.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 7445 | m.7445A\>G | A7445G\-F6 | A7445G\-F6\-III2 | Fam | ND | Y | Y | A | ND | Homo | / | / | / | Sensorineural hearing loss |  |
| 2 | 7445 | m.7445A\>G | A7445G\-F6 | A7445G\-F6\-II2 | Fam | F | N | N | A | ND | Homo | / | / | / | Normal hearing |  |
| 3 | 7445 | m.7445A\>G | A7445G\-F6 | A7445G\-F6\-I2 | Uninf | F | N | ND | A | ND | 90% | / | / | / | Healthy |  |

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