A7445G-F7

**Figure 1\. Pedigree diagram for family A7445G\-F7\.**

![](/media/202606/20260626162452050922.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 7445 | m.7445A\>G | A7445G\-F7 | Japan | Progressive sensorineural hearing loss | 0 | 6 | 2018 | [29605341](https://pubmed.ncbi.nlm.nih.gov/29605341/) |  |

The **m.7445A\>G** variant in MT\-CO1 was reported in family A7445G\-F7 from Japan with progressive sensorineural hearing loss. The pedigree record reported 0 unaffected and 6 affected maternal relatives, and the carrier table includes 2 listed carriers. Homoplasmy was reported in 0/2 listed carriers; 2/2 carriers were affected, and the main clinical manifestation among affected carriers was progressive sensorineural hearing loss in infancy, progressive sensorineural hearing loss since childhood.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 7445 | m.7445A\>G | A7445G\-F7 | A7445G\-F7\-IV2 | Fam | M | Y | Y | A | 1 | 87\.3% | / | / | 86\.3%(F) | Progressive sensorineural hearing loss in infancy |  |
| 2 | 7445 | m.7445A\>G | A7445G\-F7 | A7445G\-F7\-III4 | Fam | F | N | Y | A | ND | 86% | / | / | / | Progressive sensorineural hearing loss since childhood | Mother of proband |

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