A7445G-F5

**Figure 1\. Pedigree diagram for family A7445G\-F5\.**

![](/media/202606/20260626165655031144.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 7445 | m.7445A\>G | A7445G\-F5 | Ukraine | Nonsyndromic sensorineural hearing loss | 4 | 6 | 2001 | [11175301](https://pubmed.ncbi.nlm.nih.gov/11175301/) |  |

The **m.7445A\>G** variant in MT\-CO1 was reported in family A7445G\-F5 from Ukraine with nonsyndromic sensorineural hearing loss. The pedigree record reported 4 unaffected and 6 affected maternal relatives, and the carrier table includes 4 listed carriers. Homoplasmy was reported in all listed carriers; 4/4 carriers were affected, and the main clinical manifestation among affected carriers was progressive bilateral sensorineural hearing loss, long\-standing bilateral sensorineural hearing loss, nonsyndromic hearing impairment.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 7445 | m.7445A\>G | A7445G\-F5 | A7445G\-F5\-IV1 | Fam | F | Y | Y | A | 20 | Homo | / | / | / | Progressive bilateral sensorineural hearing loss |  |
| 2 | 7445 | m.7445A\>G | A7445G\-F5 | A7445G\-F5\-IV2 | Fam | F | N | Y | A | 15 | Homo | / | / | / | Progressive bilateral sensorineural hearing loss |  |
| 3 | 7445 | m.7445A\>G | A7445G\-F5 | A7445G\-F5\-III2 | Fam | F | N | Y | A | 28 | Homo | / | / | / | Long\-standing bilateral sensorineural hearing loss |  |
| 4 | 7445 | m.7445A\>G | A7445G\-F5 | A7445G\-F5\-III3 | Fam | M | N | Y | A | ND | Homo | / | / | / | Nonsyndromic hearing impairment |  |

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