G15927A-F6

**Figure 1\. Pedigree diagram for family G15927A\-F6\.**

![](/media/202606/20260625172638195615.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 15927 | m.15927G\>A | G15927A\-F6 | China | Coronary heart disease (CHD), hypertension, diabetes mellitus, cerebrovascular disease, left ventricular hypertrophy (LVH) | 6 | 5 | 2014 | [24470521](https://pubmed.ncbi.nlm.nih.gov/24470521/) | Carrying A5592G |

The **m.15927G\>A** variant in MT\-TT was reported in family G15927A\-F6 from China with coronary heart disease (chd), hypertension, diabetes mellitus, cerebrovascular disease, left ventricular hypertrophy (lvh). The pedigree record reported 6 unaffected and 5 affected maternal relatives, and the carrier table includes 1 listed carrier. Homoplasmy was reported in all listed carriers; 1/1 carriers were affected, and the main clinical manifestation among affected carriers was coronary heart disease (chd), hypertension, diabetes mellitus, cerebrovascular disease, left ventricular hypertrophy (lvh).

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 15927 | m.15927G\>A | G15927A\-F6 | G15927A\-F6\-III2 | Fam | F | Y | Y | A | 50 | Homo | / | / | / | Coronary heart disease (CHD), hypertension, diabetes mellitus, cerebrovascular disease, left ventricular hypertrophy (LVH) | Carrying A5592G |

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