G15927A-F2

**Figure 1\. Pedigree diagram for family G15927A\-F2\.**

![](/media/202606/20260625172516973364.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 15927 | m.15927G\>A | G15927A\-F2 | China | Bilateral profound hearing loss, gentamycin ototoxicity | 4 | 7 | 2008 | [18820594](https://pubmed.ncbi.nlm.nih.gov/18820594/) | Carrying A1555G |

The **m.15927G\>A** variant in MT\-TT was reported in family G15927A\-F2 from China with bilateral profound hearing loss, gentamycin ototoxicity. The pedigree record reported 4 unaffected and 7 affected maternal relatives, and the carrier table includes 2 listed carriers. Homoplasmy was reported in all listed carriers; 2/2 carriers were affected, and the main clinical manifestation among affected carriers was bilateral severe hearing loss, gentamycin ototoxicity, profound deafness.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 15927 | m.15927G\>A | G15927A\-F2 | G15927A\-F2\-IV2 | Fam | F | Y | Y | A | 17 | Homo | / | / | / | Bilateral severe hearing loss, gentamycin ototoxicity | Carrying A1555G |
| 2 | 15927 | m.15927G\>A | G15927A\-F2 | G15927A\-F2\-III7 | Fam | M | N | Y | A | ND | Homo | / | / | / | Profound deafness | Carrying A1555G |

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