G15950A-F2

**Figure 1\. Pedigree diagram for family G15950A\-F2\.**

![](/media/202607/G15950A-F2-pedigree_20260701032334768722.png#size=100%&align=left)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 15950 | m.15950G\>A | G15950A\-F2 | Spain | LHON | 2 | 0 | 2022 | [35808913](https://pubmed.ncbi.nlm.nih.gov/35808913/) | Carrying A4435G |

The **m.15950G\>A** variant in MT\-TT was reported in family G15950A\-F2 from Spain with lhon. The pedigree record reported 2 unaffected and 0 affected maternal relatives, and the carrier table includes 3 listed carriers. Homoplasmy was reported in all listed carriers; 1/3 carriers were affected, and the main clinical manifestation among affected carriers was lhon.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 15950 | m.15950G\>A | G15950A\-F2 | G15950A\-F2\-II1 | Fam | M | Y | Y | A | ND | Homo | / | / | / | LHON | Carrying A4435G |
| 2 | 15950 | m.15950G\>A | G15950A\-F2 | G15950A\-F2\-II2 | Fam | F | N | N | A | ND | Homo | / | / | / | Healthy |  |
| 3 | 15950 | m.15950G\>A | G15950A\-F2 | G15950A\-F2\-II3 | Fam | F | N | N | A | ND | Homo | / | / | / | Healthy |  |

For abbreviations and other usage instructions, please see [Mitofam Info](https://mitofam.com/doc/385/).