G15615A-F1

**Figure 1\. Pedigree diagram for family G15615A\-F1\.**

![](/media/202606/20260630162611196628.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 15615 | m.15615G\>A | G15615A\-F1 | France | Progressive Exercise Intolerance, Myopathy | 0 | 0 | 1996 | [8910895](https://pubmed.ncbi.nlm.nih.gov/8910895/) | PMID 8988236 is support\-only for the same patient; transmission unresolved. |

The **m.15615G\>A** variant in MT\-CYB was reported in family G15615A\-F1 from France with progressive exercise intolerance, myopathy. The pedigree record reported 0 unaffected and 0 affected maternal relatives, and the carrier table includes 1 listed carriers. Homoplasmy was reported in 0/1 listed carriers; 1/1 carriers were affected, and the main clinical manifestation among affected carriers was progressive exercise intolerance, myopathy.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 15615 | m.15615G\>A | G15615A\-F1 | G15615A\-F1\-II1 | Uninf | M | Y | Y | A | 29 | 0 | 80% | / | / | Progressive Exercise Intolerance, Myopathy | PMID 8988236 supports same patient with whole muscle about 85% and C1 pellet about 30%; transmission unresolved. |

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