G15498A-F2

**Figure 1\. Pedigree diagram for family G15498A\-F2\.**

![](/media/202606/20260630162547280884.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 15498 | m.15498G\>A | G15498A\-F2 | Japan | Sensorineural Hearing Loss (SNHL), Wolff\-Parkinson\-White (WPW) Syndrome | 9 | 1 | 2010 | [20111055](https://pubmed.ncbi.nlm.nih.gov/20111055/) |  |

The **m.15498G\>A** variant in MT\-CYB was reported in family G15498A\-F2 from Japan with sensorineural hearing loss (snhl), wolff\-parkinson\-white (wpw) syndrome. The pedigree record reported 9 unaffected and 1 affected maternal relatives, and the carrier table includes 5 listed carriers. Homoplasmy was reported in 1/5 listed carriers; 1/5 carriers were affected, and the main clinical manifestation among affected carriers was sensorineural hearing loss (snhl), wolff\-parkinson\-white (wpw) syndrome.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 15498 | m.15498G\>A | G15498A\-F2 | G15498A\-F2\-II6 | Uninf | F | Y | Y | A | 54 | Homo | / | / | / | Sensorineural Hearing Loss (SNHL), Wolff\-Parkinson\-White (WPW) Syndrome |  |
| 2 | 15498 | m.15498G\>A | G15498A\-F2 | G15498A\-F2\-III4 | Fam | M | N | N | A | ND | / | / | / | / | Healthy | No molecular testing in child; included because mother II\-6 has confirmed mutation load and child phenotype is explicitly reported. |
| 3 | 15498 | m.15498G\>A | G15498A\-F2 | G15498A\-F2\-III5 | Fam | F | N | N | A | ND | / | / | / | / | Healthy | No molecular testing in child; included because mother II\-6 has confirmed mutation load and child phenotype is explicitly reported. |
| 4 | 15498 | m.15498G\>A | G15498A\-F2 | G15498A\-F2\-III6 | Fam | F | N | N | A | ND | / | / | / | / | Healthy | No molecular testing in child; included because mother II\-6 has confirmed mutation load and child phenotype is explicitly reported. |
| 5 | 15498 | m.15498G\>A | G15498A\-F2 | G15498A\-F2\-III7 | Fam | M | N | N | A | ND | / | / | / | / | Healthy | No molecular testing in child; included because mother II\-6 has confirmed mutation load and child phenotype is explicitly reported. |

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