A1555G-F83

**Figure 1\. Pedigree diagram for family A1555G\-F83\.**

![](/media/202607/A1555G-F83-pedigree_20260701022506652664.png#size=100%&align=left)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 1555 | m.1555A\>G | A1555G\-F83 | Poland | Aminoglycoside\-induced sensorineural hearing loss | 0 | 1 | 2002 | [11857751](https://pubmed.ncbi.nlm.nih.gov/11857751/) |  |

The **m.1555A\>G** variant in MT\-RNR1 was reported in family A1555G\-F83 from Poland with aminoglycoside\-induced sensorineural hearing loss. The pedigree record reported 0 unaffected and 1 affected maternal relatives, and the carrier table includes 2 listed carriers. Homoplasmy was reported in all listed carriers; 2/2 carriers were affected, and the main clinical manifestation among affected carriers was severe hearing impairment.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 1555 | m.1555A\>G | A1555G\-F83 | A1555G\-F83\-I1 | Uninf | F | ND | Y | ND | ND | Homo | / | / | / | Severe hearing impairment | Gentamicin exposure; after gentamycin exposure |
| 2 | 1555 | m.1555A\>G | A1555G\-F83 | A1555G\-F83\-I2 | Uninf | F | ND | Y | ND | ND | Homo | / | / | / | Severe hearing impairment | Gentamicin exposure; after gentamycin exposure |

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