A1555G-F10

**Figure 1\. Pedigree diagram for family A1555G\-F10\.**

![](/media/202607/A1555G-F10-pedigree_20260701020717863012.png#size=100%&align=left)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 1555 | m.1555A\>G | A1555G\-F10 | China | Aminoglycoside\-induced and nonsyndromic hearing loss | 22 | 11 | 2006 | [16955413](https://pubmed.ncbi.nlm.nih.gov/16955413/) | Family BJ107 |

The **m.1555A\>G** variant in MT\-RNR1 was reported in family A1555G\-F10 from China with aminoglycoside\-induced and nonsyndromic hearing loss. The pedigree record reported 22 unaffected and 11 affected maternal relatives, and the carrier table includes 12 listed carriers. Homoplasmy was reported in all listed carriers; 1/12 carriers were affected, and the main clinical manifestation among affected carriers was severe hearing loss.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 1555 | m.1555A\>G | A1555G\-F10 | A1555G\-F10\-III5 | Fam | M | Y | Y | A | 48 | Homo | / | / | / | Severe hearing loss | Original carrier ID: BJ107\-III5; after streptomycin exposure |
| 2 | 1555 | m.1555A\>G | A1555G\-F10 | A1555G\-F10\-III7 | Fam | ND | ND | ND | ND | ND | Homo | / | / | / | ND | aminoglycoside exposure; matrilineal relative; severity not individually extracted; aminoglycoside: Yes |
| 3 | 1555 | m.1555A\>G | A1555G\-F10 | A1555G\-F10\-III11 | Fam | ND | ND | ND | ND | ND | Homo | / | / | / | ND | aminoglycoside exposure; matrilineal relative; duplicate OCR mention possible; aminoglycoside: Yes |
| 4 | 1555 | m.1555A\>G | A1555G\-F10 | A1555G\-F10\-II2 | Fam | F | N | ND | ND | ND | Homo | / | / | / | ND | Affected matrilineal relative in BJ107 Figure 1; no individual age/severity reported |
| 5 | 1555 | m.1555A\>G | A1555G\-F10 | A1555G\-F10\-II4 | Fam | F | N | ND | ND | ND | Homo | / | / | / | ND | Affected matrilineal relative in BJ107 Figure 1; no individual age/severity reported |
| 6 | 1555 | m.1555A\>G | A1555G\-F10 | A1555G\-F10\-II6 | Fam | F | N | ND | ND | ND | Homo | / | / | / | ND | Affected matrilineal relative in BJ107 Figure 1; no individual age/severity reported |
| 7 | 1555 | m.1555A\>G | A1555G\-F10 | A1555G\-F10\-III3 | Fam | M | N | ND | ND | ND | Homo | / | / | / | ND | Affected matrilineal relative in BJ107 Figure 1; no individual age/severity reported |
| 8 | 1555 | m.1555A\>G | A1555G\-F10 | A1555G\-F10\-III13 | Fam | F | N | ND | ND | ND | Homo | / | / | / | ND | Affected matrilineal relative in BJ107 Figure 1; starred aminoglycoside\-exposed symbol, likely the duplicated III\-11 text mention |
| 9 | 1555 | m.1555A\>G | A1555G\-F10 | A1555G\-F10\-III16 | Fam | M | N | ND | ND | ND | Homo | / | / | / | ND | Affected matrilineal relative in BJ107 Figure 1; no individual age/severity reported |
| 10 | 1555 | m.1555A\>G | A1555G\-F10 | A1555G\-F10\-III24 | Fam | M | N | ND | ND | ND | Homo | / | / | / | ND | Affected matrilineal relative in BJ107 Figure 1; no individual age/severity reported |
| 11 | 1555 | m.1555A\>G | A1555G\-F10 | A1555G\-F10\-III29 | Fam | F | N | ND | ND | ND | Homo | / | / | / | ND | Affected matrilineal relative in BJ107 Figure 1; no individual age/severity reported |
| 12 | 1555 | m.1555A\>G | A1555G\-F10 | A1555G\-F10\-IV10 | Fam | M | N | ND | ND | ND | Homo | / | / | / | ND | Affected matrilineal relative in BJ107 Figure 1; no individual age/severity reported |

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