A1555G-F70

**Figure 1\. Pedigree diagram for family A1555G\-F70\.**

![](/media/202607/A1555G-F70-pedigree_20260701022422952890.png#size=100%&align=left)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 1555 | m.1555A\>G | A1555G\-F70 | China | aminoglycoside\-induced and nonsyndromic hearing loss | 7 | 1 | 2020 | [32400865](https://pubmed.ncbi.nlm.nih.gov/32400865/) | Family 32400865 |

The **m.1555A\>G** variant in MT\-RNR1 was reported in family A1555G\-F70 from China with aminoglycoside\-induced and nonsyndromic hearing loss. The pedigree record reported 7 unaffected and 1 affected maternal relatives, and the carrier table includes 2 listed carriers. Homoplasmy was reported in 0/2 listed carriers; 2/2 carriers were affected, and the main clinical manifestation among affected carriers was profound hearing loss.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 1555 | m.1555A\>G | A1555G\-F70 | A1555G\-F70\-III3 | Fam | M | N | Y | ND | 21 | / | / | / | / | Profound hearing loss | no aminoglycoside exposure reported |
| 2 | 1555 | m.1555A\>G | A1555G\-F70 | A1555G\-F70\-III5 | Fam | F | Y | Y | ND | 25 | / | / | / | / | Profound hearing loss | aminoglycoside exposure at age 10 |

For abbreviations and other usage instructions, please see [Mitofam Info](https://mitofam.com/doc/385/).