A1555G-F24

**Figure 1\. Pedigree diagram for family A1555G\-F24\.**

![](/media/202607/A1555G-F24-pedigree_20260701021835412505.png#size=100%&align=left)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 1555 | m.1555A\>G | A1555G\-F24 | China | Aminoglycoside\-induced and nonsyndromic hearing impairment | 4 | 3 | 2008 | [18386806](https://pubmed.ncbi.nlm.nih.gov/18386806/) | Family WZD10 |

The **m.1555A\>G** variant in MT\-RNR1 was reported in family A1555G\-F24 from China with aminoglycoside\-induced and nonsyndromic hearing impairment. The pedigree record reported 4 unaffected and 3 affected maternal relatives, and the carrier table includes 7 listed carriers. Homoplasmy was reported in 5/7 listed carriers; 4/7 carriers were affected, and the main clinical manifestation among affected carriers was severe hearing impairment, pta about 67, 82 db, profound hearing impairment, severe hearing loss.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 1555 | m.1555A\>G | A1555G\-F24 | A1555G\-F24\-III2 | Fam | F | Y | Y | A | 27 | Homo | / | / | / | severe hearing impairment; PTA about 67/82 dB | Original carrier ID: WZD10\-III\-2 |
| 2 | 1555 | m.1555A\>G | A1555G\-F24 | A1555G\-F24\-II2 | Fam | F | N | Y | A | ND | Homo | / | / | / | Profound hearing impairment | Original carrier ID: WZD10\-II\-2; after streptomycin exposure; exact pedigree label ambiguous in OCR text |
| 3 | 1555 | m.1555A\>G | A1555G\-F24 | A1555G\-F24\-III3 | Fam | F | N | Y | A | ND | Homo | / | / | / | Severe hearing impairment | Original carrier ID: WZD10\-III\-3; sister; no aminoglycoside exposure reported |
| 4 | 1555 | m.1555A\>G | A1555G\-F24 | A1555G\-F24\-IV1 | Fam | M | N | Y | A | ND | / | / | / | / | Severe hearing loss | Original carrier ID: WZD10\-IV\-1; Son; no aminoglycoside exposure reported |
| 5 | 1555 | m.1555A\>G | A1555G\-F24 | A1555G\-F24\-II3 | Fam | M | N | N | ND | ND | Homo | / | / | / | Healthy | Original carrier ID: WZD10\-II\-3 |
| 6 | 1555 | m.1555A\>G | A1555G\-F24 | A1555G\-F24\-III4 | Fam | F | N | N | ND | ND | Homo | / | / | / | Healthy | Original carrier ID: WZD10\-III\-4 |
| 7 | 1555 | m.1555A\>G | A1555G\-F24 | A1555G\-F24\-IV2 | Fam | F | N | N | ND | ND | / | / | / | / | Healthy | Original carrier ID: WZD10\-IV\-2 |

For abbreviations and other usage instructions, please see [Mitofam Info](https://mitofam.com/doc/385/).