A1555G-F7

**Figure 1\. Pedigree diagram for family A1555G\-F7\.**

![](/media/202607/A1555G-F7-pedigree_20260701022413650893.png#size=100%&align=left)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 1555 | m.1555A\>G | A1555G\-F7 | China | Aminoglycoside\-induced and nonsyndromic hearing impairment | 5 | 9 | 2005 | [16168391](https://pubmed.ncbi.nlm.nih.gov/16168391/) | Family BJ105 |

The **m.1555A\>G** variant in MT\-RNR1 was reported in family A1555G\-F7 from China with aminoglycoside\-induced and nonsyndromic hearing impairment. The pedigree record reported 5 unaffected and 9 affected maternal relatives, and the carrier table includes 3 listed carriers. Homoplasmy was reported in all listed carriers; 1/3 carriers were affected, and the main clinical manifestation among affected carriers was severe bilateral sensorineural hearing impairment, pta about 80, 86 db, slope audiogram.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 1555 | m.1555A\>G | A1555G\-F7 | A1555G\-F7\-III2 | Fam | F | Y | Y | A | 18 | Homo | / | / | / | Severe bilateral sensorineural hearing impairment; PTA about 80/86 dB; slope audiogram | Original carrier ID: BJ105\-III\-2; after streptomycin exposure at age 17 for tuberculosis |
| 2 | 1555 | m.1555A\>G | A1555G\-F7 | A1555G\-F7\-III3 | Fam | ND | N | ND | A | ND | Homo | / | / | / | ND | Original carrier ID: BJ105\-III\-3; matrilineal relative; aminoglycoside exposure reported for the affected relative group |
| 3 | 1555 | m.1555A\>G | A1555G\-F7 | A1555G\-F7\-II15 | Fam | ND | N | ND | ND | ND | Homo | / | / | / | ND | Original carrier ID: BJ105\-II\-15; aminoglycoside exposure; matrilineal relative |

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