T3396C-F1

**Figure 1\. Pedigree diagram for family T3396C\-F1\.**

![](/media/202606/20260630034817722397.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 3396 | m.3396T\>C | T3396C\-F1 | Tunisia | Nonsyndromic hearing loss | 1 | 2 | 2007 | [17336924](https://pubmed.ncbi.nlm.nih.gov/17336924/) | Carrying A3243G. |

The **m.3396T\>C** variant in MT\-ND1 was reported in family T3396C\-F1 from Tunisia with nonsyndromic hearing loss. The pedigree record reported 1 unaffected and 2 affected maternal relatives, and the carrier table includes 4 listed carriers. Homoplasmy was reported in all listed carriers; 3/4 carriers were affected, and the main clinical manifestation among affected carriers was nonsyndromic hearing loss.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 3396 | m.3396T\>C | T3396C\-F1 | T3396C\-F1\-III1 | Fam | F | N | Y | A | ND | Homo | / | / | / | Nonsyndromic hearing loss |  |
| 2 | 3396 | m.3396T\>C | T3396C\-F1 | T3396C\-F1\-IV2 | Fam | F | N | N | A | ND | Homo | / | / | / | Normal hearing |  |
| 3 | 3396 | m.3396T\>C | T3396C\-F1 | T3396C\-F1\-V1 | Fam | M | Y | Y | A | ND | Homo | / | / | / | Nonsyndromic hearing loss |  |
| 4 | 3396 | m.3396T\>C | T3396C\-F1 | T3396C\-F1\-V2 | Fam | F | N | Y | A | ND | Homo | / | / | / | Nonsyndromic hearing loss |  |

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