G3697A-F4

**Figure 1\. Pedigree diagram for family G3697A\-F4\.**

![](/media/202606/20260630033642999373.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 3697 | m.3697G\>A | G3697A\-F4 | China | Leigh syndrome | 3 | 0 | 2021 | [34802141](https://pubmed.ncbi.nlm.nih.gov/34802141/) |  |

The **m.3697G\>A** variant in MT\-ND1 was reported in family G3697A\-F4 from China with leigh syndrome. The pedigree record reported 3 unaffected and 0 affected maternal relatives, and the carrier table includes 4 listed carriers. Homoplasmy was reported in 0/4 listed carriers; 1/4 carriers were affected, and the main clinical manifestation among affected carriers was leigh syndrome.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 3697 | m.3697G\>A | G3697A\-F4 | G3697A\-F4\-I2 | Uninf | F | N | N | A | ND | 75\.16% | / | / | / | Healthy |  |
| 2 | 3697 | m.3697G\>A | G3697A\-F4 | G3697A\-F4\-II2 | Fam | F | N | N | A | 30 | 55\.97% | / | / | / | Healthy |  |
| 3 | 3697 | m.3697G\>A | G3697A\-F4 | G3697A\-F4\-II3 | Fam | M | N | N | A | ND | 57\.77% | / | / | / | Healthy |  |
| 4 | 3697 | m.3697G\>A | G3697A\-F4 | G3697A\-F4\-III1 | Fam | F | Y | Y | A | 2 | 99% | / | / | / | Leigh syndrome |  |

For abbreviations and other usage instructions, please see [Mitofam Info](https://mitofam.com/doc/385/).