A13637G-F1

**Figure 1\. Pedigree diagram for family A13637G\-F1\.**

![](/media/202607/A13637G-F1-pedigree_20260701012945398236.png#size=100%&align=left)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 13637 | m.13637A\>G | A13637G\-F1 | Latvia | LHON | 2 | 0 | 2013 | [24319328](https://pubmed.ncbi.nlm.nih.gov/24319328/) | Family F2; Tables 1\-2 and second\-family paragraph.; Latvia; Latvian population and Riga/Latvian institutions. |

The **m.13637A\>G** variant in MT\-ND5 was reported in family A13637G\-F1 from Latvia with lhon. The pedigree record reported 2 unaffected and 0 affected maternal relatives, and the carrier table includes 3 listed carriers. Homoplasmy was reported in all listed carriers; 1/3 carriers were affected, and the main clinical manifestation among affected carriers was lhon, visual acuity 0\.05, 0\.06, cecocentral scotomas.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 13637 | m.13637A\>G | A13637G\-F1 | A13637G\-F1\-I2 | Fam | F | Y | Y | A | onset 40 y; tested 55 y | Homo | / | / | / | LHON; visual acuity 0\.05/0\.06; cecocentral scotomas | Tables 1\-2 and second\-family text.; Source: LHON\-4 |
| 2 | 13637 | m.13637A\>G | A13637G\-F1 | A13637G\-F1\-II1 | Fam | F | N | N | A | 24 y | Homo | / | / | / | Healthy | Tables 1\-2 and second\-family text.; Source: LHON\-6 |
| 3 | 13637 | m.13637A\>G | A13637G\-F1 | A13637G\-F1\-II2 | Fam | F | N | N | A | 32 y | Homo | / | / | / | Healthy | Tables 1\-2 and second\-family text.; Source: LHON\-7 |

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