A13528G-F6

**Figure 1\. Pedigree diagram for family A13528G\-F6\.**

![](/media/202607/A13528G-F6-pedigree_20260701012925278620.png#size=100%&align=left)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 13528 | m.13528A\>G | A13528G\-F6 | USA inferred | autism spectrum disorder | 0 | 3 | 2017 | [28419775](https://pubmed.ncbi.nlm.nih.gov/28419775/) | Use cautiously: individual labels/genders/ages/load absent; only aggregate family\-level affected sibling evidence is available.; ASD family 74\-0733; pages 1\-4; USA inferred from ASD cohort/source and affiliations. |

The **m.13528A\>G** variant in MT\-ND5 was reported in family A13528G\-F6 from USA inferred with autism spectrum disorder. The pedigree record reported 0 unaffected and 3 affected maternal relatives, and the carrier table includes 4 listed carriers. Homoplasmy was reported in 0/4 listed carriers; 4/4 carriers were affected, and the main clinical manifestation among affected carriers was autism spectrum disorder..

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 13528 | m.13528A\>G | A13528G\-F6 | A13528G\-F6\-II1 | Fam | ND | N | Y | A | ND | / | / | / | Positive(LCL) | Autism spectrum disorder. | Anonymous carrier; family also has m.13565C\>T.; pages 1\-4; Source: affected sibling 1 |
| 2 | 13528 | m.13528A\>G | A13528G\-F6 | A13528G\-F6\-II3 | Fam | ND | N | Y | A | ND | / | / | / | Positive(LCL) | Autism spectrum disorder. | Anonymous carrier; family also has m.13565C\>T.; pages 1\-4; Source: affected sibling 2 |
| 3 | 13528 | m.13528A\>G | A13528G\-F6 | A13528G\-F6\-II4 | Fam | ND | N | Y | A | ND | / | / | / | Positive(LCL) | Autism spectrum disorder. | Anonymous carrier; family also has m.13565C\>T.; pages 1\-4; Source: affected sibling 3 |
| 4 | 13528 | m.13528A\>G | A13528G\-F6 | A13528G\-F6\-II5 | Fam | ND | N | Y | A | ND | / | / | / | Positive(LCL) | Autism spectrum disorder. | Anonymous carrier; family also has m.13565C\>T.; pages 1\-4; Source: affected sibling 4 |

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