T7510C-F4

**Figure 1\. Pedigree diagram for family T7510C\-F4\.**

![](/media/202606/20260622191038398363.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 7510 | m.7510T\>C | T7510C\-F4 | Hungary | Hearing loss | 1 | 4 | 2013 | [23430555](https://pubmed.ncbi.nlm.nih.gov/23430555/) |  |

The **m.7510T\>C** variant in MT\-TS1 was reported in family T7510C\-F4 from Hungary with hearing loss. The pedigree record reported 1 unaffected and 4 affected maternal relatives, and the carrier table includes 6 listed carriers. Homoplasmy was reported in 3/6 listed carriers; 5/6 carriers were affected, and the main clinical manifestation among affected carriers was hearing loss.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 7510 | m.7510T\>C | T7510C\-F4 | T7510C\-F4\-I2 | Uninf | F | N | Y | D | \<30 | / | / | / | / | Hearing loss |  |
| 2 | 7510 | m.7510T\>C | T7510C\-F4 | T7510C\-F4\-II2 | Fam | F | N | Y | A | 20 | Homo | / | / | / | Hearing loss |  |
| 3 | 7510 | m.7510T\>C | T7510C\-F4 | T7510C\-F4\-II3 | Fam | F | N | Y | A | 20 | / | / | / | / | Hearing loss |  |
| 4 | 7510 | m.7510T\>C | T7510C\-F4 | T7510C\-F4\-III2 | Fam | F | N | Y | A | 20 | Homo | / | / | / | Hearing loss |  |
| 5 | 7510 | m.7510T\>C | T7510C\-F4 | T7510C\-F4\-IV1 | Fam | M | Y | Y | A | 5 | Homo | / | / | / | Hearing loss |  |
| 6 | 7510 | m.7510T\>C | T7510C\-F4 | T7510C\-F4\-IV2 | Fam | F | N | N | A | 3 | / | / | / | / | Healthy |  |

For abbreviations and other usage instructions, please see [Mitofam Info](https://mitofam.com/doc/385/).