T7510C-F3

**Figure 1\. Pedigree diagram for family T7510C\-F3\.**

![](/media/202606/20260622190955283301.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 7510 | m.7510T\>C | T7510C\-F3 | USA | Hearing loss | 0 | 15 | 2008 | [18028453](https://pubmed.ncbi.nlm.nih.gov/18028453/) |  |

The **m.7510T\>C** variant in MT\-TS1 was reported in family T7510C\-F3 from USA with hearing loss. The pedigree record reported 0 unaffected and 15 affected maternal relatives, and the carrier table includes 16 listed carriers. Homoplasmy was reported in 11/16 listed carriers; 16/16 carriers were affected, and the main clinical manifestation among affected carriers was hearing loss.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 7510 | m.7510T\>C | T7510C\-F3 | T7510C\-F3\-I2 | Uninf | F | N | Y | D | ND | / | / | / | / | Hearing loss |  |
| 2 | 7510 | m.7510T\>C | T7510C\-F3 | T7510C\-F3\-II2 | Fam | F | N | Y | A | ND | Homo | / | / | / | Hearing loss |  |
| 3 | 7510 | m.7510T\>C | T7510C\-F3 | T7510C\-F3\-II3 | Fam | F | N | Y | D | ND | / | / | / | / | Hearing loss |  |
| 4 | 7510 | m.7510T\>C | T7510C\-F3 | T7510C\-F3\-II4 | Fam | M | N | Y | D | ND | / | / | / | / | Hearing loss |  |
| 5 | 7510 | m.7510T\>C | T7510C\-F3 | T7510C\-F3\-II5 | Fam | M | N | Y | D | ND | / | / | / | / | Hearing loss |  |
| 6 | 7510 | m.7510T\>C | T7510C\-F3 | T7510C\-F3\-II6 | Fam | F | N | Y | D | ND | / | / | / | / | Hearing loss |  |
| 7 | 7510 | m.7510T\>C | T7510C\-F3 | T7510C\-F3\-III2 | Fam | F | Y | Y | A | ND | Homo | / | / | / | Hearing loss |  |
| 8 | 7510 | m.7510T\>C | T7510C\-F3 | T7510C\-F3\-III3 | Fam | F | N | Y | A | ND | Homo | / | / | / | Hearing loss |  |
| 9 | 7510 | m.7510T\>C | T7510C\-F3 | T7510C\-F3\-III4 | Fam | F | N | Y | A | ND | Homo | / | / | / | Hearing loss |  |
| 10 | 7510 | m.7510T\>C | T7510C\-F3 | T7510C\-F3\-III5 | Fam | M | N | Y | A | ND | Homo | / | / | / | Hearing loss |  |
| 11 | 7510 | m.7510T\>C | T7510C\-F3 | T7510C\-F3\-III7 | Fam | M | N | Y | A | ND | Homo | / | / | / | Hearing loss |  |
| 12 | 7510 | m.7510T\>C | T7510C\-F3 | T7510C\-F3\-III9 | Fam | M | N | Y | A | ND | Homo | / | / | / | Hearing loss |  |
| 13 | 7510 | m.7510T\>C | T7510C\-F3 | T7510C\-F3\-IV1 | Fam | M | N | Y | A | ND | Homo | / | / | / | Hearing loss |  |
| 14 | 7510 | m.7510T\>C | T7510C\-F3 | T7510C\-F3\-IV2 | Fam | F | N | Y | A | ND | Homo | / | / | / | Hearing loss |  |
| 15 | 7510 | m.7510T\>C | T7510C\-F3 | T7510C\-F3\-IV3 | Fam | M | N | Y | A | ND | Homo | / | / | / | Hearing loss |  |
| 16 | 7510 | m.7510T\>C | T7510C\-F3 | T7510C\-F3\-IV4 | Fam | F | N | Y | A | ND | Homo | / | / | / | Hearing loss |  |

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