T7505C-F1

**Figure 1\. Pedigree diagram for family T7505C\-F1\.**

![](/media/202606/20260622185051807799.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 7505 | m.7505T\>C | T7505C\-F1 | China | Hearing loss | 2 | 6 | 2010 | [20153673](https://pubmed.ncbi.nlm.nih.gov/20153673/) |  |

The **m.7505T\>C** variant in MT\-TS1 was reported in family T7505C\-F1 from China with hearing loss. The pedigree record reported 2 unaffected and 6 affected maternal relatives, and the carrier table includes 9 listed carriers. Homoplasmy was reported in all listed carriers; 7/9 carriers were affected, and the main clinical manifestation among affected carriers was hearing loss.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 7505 | m.7505T\>C | T7505C\-F1 | T7505C\-F1\-I2 | Uninf | F | N | Y | A | 18 | Homo | / | / | / | Hearing loss |  |
| 2 | 7505 | m.7505T\>C | T7505C\-F1 | T7505C\-F1\-II2 | Fam | F | N | Y | A | 8 | Homo | / | / | / | Hearing loss |  |
| 3 | 7505 | m.7505T\>C | T7505C\-F1 | T7505C\-F1\-II4 | Fam | M | N | Y | A | 6 | Homo | / | / | / | Hearing loss |  |
| 4 | 7505 | m.7505T\>C | T7505C\-F1 | T7505C\-F1\-II6 | Fam | M | N | Y | A | 5 | Homo | / | / | / | Hearing loss |  |
| 5 | 7505 | m.7505T\>C | T7505C\-F1 | T7505C\-F1\-II9 | Fam | F | N | Y | A | 7 | Homo | / | / | / | Hearing loss |  |
| 6 | 7505 | m.7505T\>C | T7505C\-F1 | T7505C\-F1\-III1 | Fam | M | Y | Y | A | 3 | Homo | / | / | / | Hearing loss |  |
| 7 | 7505 | m.7505T\>C | T7505C\-F1 | T7505C\-F1\-III2 | Fam | M | N | N | A | 3 | Homo | / | / | / | Healthy |  |
| 8 | 7505 | m.7505T\>C | T7505C\-F1 | T7505C\-F1\-III6 | Fam | M | N | N | A | 4 | Homo | / | / | / | Healthy |  |
| 9 | 7505 | m.7505T\>C | T7505C\-F1 | T7505C\-F1\-III7 | Fam | F | N | Y | A | 10 | Homo | / | / | / | Hearing loss |  |

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