G5821A-F1

**Figure 1\. Pedigree diagram for family G5821A\-F1\.**

![](/media/202606/20260622112654965006.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 5821 | m.5821G\>A | G5821A\-F1 | China | Hypertension | 1 | 3 | 2017 | [28259969](https://pubmed.ncbi.nlm.nih.gov/28259969/) | Carrying homo A4401G |

The **m.5821G\>A** variant in MT\-TC was reported in family G5821A\-F1 from China with hypertension. The pedigree record reported 1 unaffected and 3 affected maternal relatives, and the carrier table includes 5 listed carriers. Homoplasmy was reported in all listed carriers; 4/5 carriers were affected, and the main clinical manifestation among affected carriers was hypertension.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 5821 | m.5821G\>A | G5821A\-F1 | G5821A\-F1\-I2 | uninf | F | N | Y | A | 83 | Homo | / | / | / | Hypertension | Carrying homo A4401G |
| 2 | 5821 | m.5821G\>A | G5821A\-F1 | G5821A\-F1\-II1 | fam | M | N | N | A | ND | Homo | / | / | / | Healthy | Carrying homo A4401G |
| 3 | 5821 | m.5821G\>A | G5821A\-F1 | G5821A\-F1\-II3 | fam | M | N | Y | A | 57 | Homo | / | / | / | Hypertension | Carrying homo A4401G |
| 4 | 5821 | m.5821G\>A | G5821A\-F1 | G5821A\-F1\-II6 | fam | F | Y | Y | A | 59 | Homo | / | / | / | Hypertension | Carrying homo A4401G |
| 5 | 5821 | m.5821G\>A | G5821A\-F1 | G5821A\-F1\-III4 | fam | F | N | Y | A | 35 | Homo | / | / | / | Hypertension | Carrying homo A4401G |

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