T14577C-F1

**Figure 1\. Pedigree diagram for family T14577C\-F1\.**

![](/media/202606/20260630180948559581.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 14577 | m.14577T\>C | T14577C\-F1 | Japan | Maternally inherited type 2 diabetes | 1 | 4 | 2000 | [10909988](https://pubmed.ncbi.nlm.nih.gov/10909988/) |  |

The **m.14577T\>C** variant in MT\-ND6 was reported in family T14577C\-F1 from Japan with maternally inherited type 2 diabetes. The pedigree record reported 1 unaffected and 4 affected maternal relatives, and the carrier table includes 6 listed carriers. Homoplasmy was reported in 0/6 listed carriers; 5/6 carriers were affected, and the main clinical manifestation among affected carriers was type 2 diabetes, 22\-year known duration, oral agents, mild neuropathy, impaired glucose tolerance.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 14577 | m.14577T\>C | T14577C\-F1 | T14577C\-F1\-III12 | Fam | F | Y | Y | A | 69 | 98\.9% | / | / | Positive (BM/F/cybrid cells) | Type 2 diabetes; 22\-year known duration; oral agents; mild neuropathy |  |
| 2 | 14577 | m.14577T\>C | T14577C\-F1 | T14577C\-F1\-III9 | Fam | F | N | Y | A | ND | positive; load NR | / | / | / | Type 2 diabetes |  |
| 3 | 14577 | m.14577T\>C | T14577C\-F1 | T14577C\-F1\-III10 | Fam | F | N | Y | A | ND | positive; load NR | / | / | / | Type 2 diabetes | Using insulin |
| 4 | 14577 | m.14577T\>C | T14577C\-F1 | T14577C\-F1\-IV10 | Fam | F | N | Y | A | ND | positive; load NR | / | / | / | Type 2 diabetes |  |
| 5 | 14577 | m.14577T\>C | T14577C\-F1 | T14577C\-F1\-IV11 | Fam | F | N | N | A | ND | positive; load NR | / | / | / | Healthy |  |
| 6 | 14577 | m.14577T\>C | T14577C\-F1 | T14577C\-F1\-IV12 | Fam | M | N | Y | A | ND | positive; load NR | / | / | / | Impaired glucose tolerance |  |

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