G15967A-F1

**Figure 1\. Pedigree diagram for family G15967A\-F1\.**

![](/media/202606/20260629234344445951.png)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 15967 | m.15967G\>A | G15967A\-F1 | UK | MERRF | 3 | 0 | 2009 | [19273760](https://pubmed.ncbi.nlm.nih.gov/19273760/) |  |

The **m.15967G\>A** variant in MT\-TP was reported in family G15967A\-F1 from UK with merrf. The pedigree record reported 3 unaffected and 0 affected maternal relatives, and the carrier table includes 4 listed carriers. Homoplasmy was reported in 0/4 listed carriers; 2/4 carriers were affected, and the main clinical manifestation among affected carriers was merrf, severe reading disorder.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 15967 | m.15967G\>A | G15967A\-F1 | G15967A\-F1\-III2 | De novo | F | Y | Y | A | 49 | 0% | 69% | 10% | / | MERRF |  |
| 2 | 15967 | m.15967G\>A | G15967A\-F1 | G15967A\-F1\-IV1 | Fam | F | N | N | A | ND | ND | ND | ND | ND | Healthy |  |
| 3 | 15967 | m.15967G\>A | G15967A\-F1 | G15967A\-F1\-IV2 | Fam | F | N | N | A | ND | ND | ND | ND | ND | Healthy |  |
| 4 | 15967 | m.15967G\>A | G15967A\-F1 | G15967A\-F1\-IV3 | Fam | F | N | Y | A | ND | ND | ND | ND | ND | Severe reading disorder |  |

For abbreviations and other usage instructions, please see [Mitofam Info](https://mitofam.com/doc/385/).