T10663C-F1

**Figure 1\. Pedigree diagram for family T10663C\-F1\.**

![](/media/202607/T10663C-F1-pedigree_20260701012615169150.png#size=100%&align=left)

# Pedigree Information

| **No.** | **Position** | **Variant** | **Family ID** | **Nationality** | **Diseases** | **Unaffected Maternal Relatives** | **Affected Maternal Relatives** | **Publication Year** | **PMID/Ref** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 10663 | m.10663T\>C | T10663C\-F1 | Germany | LHON | 2 | 1 | 1995 | [8680405](https://pubmed.ncbi.nlm.nih.gov/8680405/) | Carrying T4216C, G13708A, G15257A |

The **m.10663T\>C** variant in MT\-ND4L was reported in family T10663C\-F1 from Germany with lhon. The pedigree record reported 2 unaffected and 1 affected maternal relatives, and the carrier table includes 4 listed carriers. Homoplasmy was reported in all listed carriers; 1/4 carriers were affected, and the main clinical manifestation among affected carriers was rapid onset painless bilateral optic atrophy, central, cecocentral scotoma, optic disk pallor, telangiectasia, tortuous vessels.

# Carrier Information

| **No.** | **Position** | **Variant** | **Family ID** | **Carrier ID** | **Type (Fam/De novo/Uninf)** | **Gender (F/M)** | **Proband (Y/N)** | **Affected (Y/N)** | **Die/Alive(D/A)** | **Age** | **Blood Mutant Level** | **Muscle Mutant level** | **Urine Mutant level** | **Other Mutant level** | **Clinical Features** | **Note** |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 10663 | m.10663T\>C | T10663C\-F1 | T10663C\-F1\-I1 | Uninf | F | N | N | A | ND | Homo | / | / |  | Color blindness and fundus changes |  |
| 2 | 10663 | m.10663T\>C | T10663C\-F1 | T10663C\-F1\-Ⅱ1 | Fam | M | Y | Y | A | 15 | Homo | / | / |  | Rapid onset painless bilateral optic atrophy; central/cecocentral scotoma; optic disk pallor; telangiectasia/tortuous vessels | Carrying T4216C, G13708A, G15257A |
| 3 | 10663 | m.10663T\>C | T10663C\-F1 | T10663C\-F1\-II2 | Fam | M | N | N | A | ND | Homo | / | / |  | Healthy |  |
| 4 | 10663 | m.10663T\>C | T10663C\-F1 | T10663C\-F1\-II3 | Fam | ND | N | N | ND | ND | Homo | / | / |  | Healthy |  |

For abbreviations and other usage instructions, please see [Mitofam Info](https://mitofam.com/doc/385/).